Show:
CASE 1
Case 2
Case 3
Case 4
Case 5
100

Heart Failure is mainly associated with which type of scleroderma. and give mechanism.

Diffuse Type

100

Drug which can cause SLE.
 

Hydralazine, Procainamide, INH, Methyldopa.

100

Treatment of choice for Scleroderma Renal Crisis.

ACE Inhibitors.

100

Most common Sequela of Barrets Esophagous in Scleroderma.

Esophageal Adenocarcinoma.

100

Reason of anemia occur in Scleroderma.
 
 

Malabsorption of iron.

200

Valve Involved in Libman-Sacs endocarditis.
 

200

A patient with asthma, eosinophilia, and systemic vasculitis.

Eosinophilic Granulomatosis with Polyangiitis

200

A patient with livedo reticularis, hypertension, and visceral artery aneurysms.

Polyarteritis Nodosa

200

Imaging method used to detect aneurysms of medium-sized arteries in polyarteritis nodosa.

Angiography

200

This cytokine plays a central role in the pathogenesis of giant cell arteritis and is the therapeutic target of tocilizumab.
 

Interleukin-6

300

A patient with oral ulcers, genital ulcers, uveitis, and vascular thrombosis.

Behçet’s Disease

300

The immunoglobulin predominantly involved in immune complex deposition in Henoch-Schönlein purpura.

IgA

300

ANCA antigen most commonly associated with granulomatosis with polyangiitis.
 

Proteinase-3

300

Histological feature of granulomatous vasculitis in GPA.

Necrotizing granulomas

300

Procedure used to remove circulating antibodies in severe ANCA-associated vasculitis.
 

Plasmapheresis
 

400

Criteria for Giant Cell Arteritis (GCA)

  • Classification requires ≥3 of following: 
    1. Age ≥ 50 years at onset
    2. New localized headache
    3. Temporal artery tenderness or decreased pulse
    4. Elevated ESR ≥ 50 mm/hr
    5. Biopsy showing necrotizing arteritis with granulomatous inflammation and multinucleated giant cells
400

Criteria for Takayasu Arteritis (TA)

  • Classification requires ≥3 of following: 
    1. Angiographic abnormalities of aorta or its main branches (mandatory)
    2. Decreased peripheral artery pulse(s) and/or claudication
    3. Blood pressure difference > 10 mmHg between limbs
    4. Bruits over aorta or major branches
    5. Hypertension (according to age-appropriate norms) 
400

Criteria for Granulomatosis with Polyangiitis (GPA)

Classification requires ≥2 of following: 

  1. Nasal or oral inflammation (ulcers, bloody/purulent discharge)
  2. Abnormal chest imaging (nodules, infiltrates, cavities)
  3. Urinary sediment with microscopic hematuria or red cell casts
  4. Granulomatous inflammation on biopsy (arterial wall or perivascular)
  1. Granulomatous inflammation on biopsy of an artery or perivascular area
  2. Positive c-ANCA (PR3-ANCA)
400

Criteria for Eosinophilic Granulomatosis with Polyangiitis (EGPA)

Classification requires ≥4 of following: 

  1. Asthma
  2. Eosinophilia > 10% on differential leukocyte count
  3. Mononeuropathy or polyneuropathy
  4. Non-fixed pulmonary infiltrates
  5. Paranasal sinus abnormality
  6. Biopsy containing a blood vessel with extravascular eosinophils
400

Criteria for Microscopic Polyangiitis (MPA)

Key classification elements (2022 ACR/EULAR): 

  1. Necrotizing vasculitis predominantly of small vessels (capillaries, venules, arterioles)
  2. p‑ANCA (MPO‑ANCA) positive
  3. No granulomatous inflammation
  4. Pulmonary capillaritis/hemorrhage present or
  5. Renal involvement (necrotizing glomerulonephritis)
500

Criteria for IgA Vasculitis (Henoch–Schönlein Purpura)

ACR 1990 & EULAR/PReS components include: 

  1. Palpable purpura (mandatory for EULAR criteria)
  2. Abdominal pain
  3. Arthritis or arthralgia
  4. Renal involvement (hematuria and/or proteinuria)
  5. IgA deposition on biopsy

(Note: Updated EULAR/PReS criteria emphasize palpable purpura plus ≥ 1 additional feature.

500

Criteria for Polyarteritis Nodosa (PAN)

Polyarteritis Nodosa (PAN) — ACR 1990

Classification requires ≥3 of following: 

  1. Weight loss ≥ 4.5 kg
  2. Livedo reticularis
  3. Testicular pain/tenderness
  4. Myalgia, weakness, or leg tenderness
  5. Mononeuropathy or polyneuropathy
  6. Diastolic BP > 90 mmHg
  7. Elevated BUN or creatinine unrelated to glomerulonephritis
  8. Hepatitis B surface antigen/antibody positive
  9. Arteriographic abnormalities (aneurysms or stenosis)
  10. Biopsy showing arteritis of medium/small artery
500

Criteria for Kawasaki Disease

Classic diagnostic features include: 

  1. Fever for ≥ 5 days
  2. Conjunctival injection
  3. Oral mucous changes
  4. Extremity changes (erythema, edema, desquamation)
  5. Polymorphous rash and cervical lymphadenopathy
500

 Criteria for Behçet Disease


Classification involves: 

  1. Recurrent oral ulcers
  2. Genital ulcers
  3. Eye lesions (uveitis)
  4. Skin lesions
  5. Pathergy test
    (Points assigned; score ≥ 4 confirms diagnosis.)
500

This type of skin change, appearing as a net-like pattern, is included in the ACR criteria for PAN.
 

 livedo reticularis?