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Guys?
100

The "Smiley" or "happy-face" emoticon can be composed of a colon, an optional hyphen for a nose, and this symbol

The "Greater Than" sign

>

100

A Microsoft product specializing in spreadsheets

Excel

100

A 2017 music video for a Luis Fonsi lead single

Despacito

100

The E in EDM

Electronic

100

He's going to take you to Flavortown

Guy Fieri

200

Arguably the most common musical scale in composition, with no sharps or flats (when began with C)

The Major Scale

200

One basic unit of biological life 

A Cell

200

This is when Wiz Khalifa will See You, according to a 2015 music video

Again

200

The E in PETA

Ethical

200

An instrument for the measurement of radiation—and making a haunting sound

Geiger Counter

300

This observation states that the number of transistors on microchips doubles every two years (you won't be thrown in jail if you break it, despite the name)

Moore's Law

300

Hard rocker that must be an expert in both 'firearms and flowers'

Axl Rose

300

Abstracting in this series that began in 2023 would be quite the "in-tents" experience

The Amazing Digital Circus

300

The E in A&E

Entertainment

300

You will likely remember-remember this man from a failed plot in 1605 (he is far from anonymous, surprisingly)

Guy Fawkes

400

A venerable title for a woman leading a convent

Mother Superior

400

Fighting game character that's good at long ranges... If only he could away from all those Sinful Sprockets

Axl Low

400

A 56-second-long video from 2007 featuring someone named Harry getting injured (though they were okay enough to complain about it)

Charlie bit my finger – again!

400

The E in JPEG

Experts

400

This Chicago-born nerd was "Ernest" in his interest in both serpents and sepulchers

Gary Gygax

500

1999 alt-rock hit peaking at #7 on the US Billboard Hot 100 off of 'Human Clay'

Higher

500

The Nobody of Lea

Axel

500

Watch out for these while traversing parallel universes im-press-ively!

Rolling Rocks

500

Euler's Number (approximately)

2.71828

500

It first emerged in 1988, with a "forth" title (despite over a dozen entries in the series) from October of 2025

Ninja Gaiden