Breztri Fundamentals
Breztri combines these three classes to treat COPD.
What are an ICS (budesonide), a LAMA (glycopyrrolate), and a LABA (formoterol)?
In pivotal trials, Breztri reduced this clinically significant outcome versus dual therapy.
What are moderate/severe COPD exacerbations?
Patients with a history of these events despite dual therapy may be candidates for Breztri.
What are frequent or recent COPD exacerbations?
Advise this simple step after inhalation to reduce thrush risk.
What is rinse mouth and spit?
Many patients are on this bronchodilator combination before stepping up to triple therapy.
What is LABA/LAMA?
Breztri is indicated for maintenance treatment of this disease, including reduction of exacerbations.
What is COPD (chronic obstructive pulmonary disease)?
Breztri improved this spirometric parameter compared to comparators.
What is FEV1?
COPD patients with this inflammatory profile may benefit from ICS-containing regimens.
What is eosinophilic/type 2–associated COPD (higher blood eosinophils)?
ICS‑containing COPD regimens carry a risk for this infection; monitor accordingly.
What is pneumonia?
The main reason to step up to triple therapy is to reduce these.
What are exacerbations?
Adding ICS to LABA/LAMA aims to reduce these events in eosinophil‑associated COPD.
What are exacerbations?
Trials showed longer time to first exacerbation with Breztri versus this regimen.
What is LABA/LAMA dual therapy?
Breztri is not indicated for treating this acute condition.
What is acute bronchospasm or acute deteriorations requiring rescue therapy?
Use caution in patients with these conditions due to LABA/LAMA effects.
What are coronary disease, arrhythmias, or hypertension?
Link value to reductions in this driver of hospitalizations and total cost of care.
What are moderate/severe exacerbations?
Compared with dual bronchodilation alone, Breztri offers this incremental benefit for selected patients.
What is reduced exacerbation risk via anti-inflammatory ICS add-on?
Patients reported improvements in dyspnea and health status on these questionnaires.
What are tools like TDI and SGRQ (dyspnea and quality-of-life measures)?
Counseling should include this foundational lifestyle recommendation for all COPD patients.
What is smoking cessation support?
Avoid use in patients with known hypersensitivity to these components.
What are budesonide, glycopyrrolate, formoterol, or excipients?
For patients who struggle with high inspiratory flow required by some DPIs, Breztri offers this device advantage.
What is pMDI delivery with Aerosphere co-suspension?
Breztri uses this formulation approach to aid delivery across diverse inhalation profiles.
What is Aerosphere pMDI technology (co-suspension for consistent particle delivery)?
Exacerbation reduction is more pronounced in patients with this blood marker threshold.
What is elevated blood eosinophils (e.g., ≥100–300 cells/µL, per study analyses)?
Consider ICS-containing therapy in patients with overlapping features of this airway disease.
What is asthma–COPD overlap (ACO), per clinician judgment and label consistency?
Repeated high ICS exposure may contribute to these systemic risks.
What are adrenal suppression, bone effects, or hyperglycemia (context-dependent)?
When clinicians query “who benefits from ICS,” point to this practical lab metric.
What is blood eosinophil count as a guide to ICS responsiveness?