Diarrhea
what medication is the combination of omeprazole and sodium bicarb?
Zegerid
when would you advise your pt to take their proton pump inhibitor?
take 30-60 minutes before a meal
whats the main concern with PPIs?
issues with chronic use
what drug can you not give PPI with?
clopidogrel
what medication is a potassium competitive acid blocker?
vonoprazan
if plavix is a substrate of CYP2C19 and omeprazole is an inhibitor of CYP2C19, what happens levels of plavix if given together?
it decreases levels of plavix
in what cells in the gastric gland are the primary site of action PPIs and PCAB
parietal cells
how long do PPI effects persist?
until new pumps are synthesized
are PPIs reversible?
no
name a PPI
omeprazole
when are proton pumps most active?
while eating a meal
what is an indication for PPIs?
GERD
erosive esophagitis
gastric+duodenal ulcers
H. pylori eradication
Zollinger-Ellison syndrome
upper GI bleeding
what pumps do PPIs act on?
active
which PPIs have IV formulations?
esomeprazole
pantoprazole
rabeprazole
what would happen if a pt was taking ketoconazole and a PPI?
fungal infection would not be treated
how are PPIs primarily cleared?
hepatic clearance (liver)
when should you take vonoprazan?
it can be taken at any time
what bacteria is treated using a combination PPI/PCAB/Abx?
H. pylori
what are PPIs classified as?
prodrugs
name a common adverse side effect of PCAB
GI
URI
UTI