Menopause
Endometrial Hyperplasia is a concern with which route(s) of Estrogen Therapy?
Oral and Transdermal (Not vaginal)
For a patient at high risk (>20%) of fracture with no history of previous fracture and impaired kidney function (25ml/min) which agent would be preferred?
Denosumab
Can systemic and vaginal estrogen be combined? Explain why or why not.
If a patient is experiencing VMS and GSM it is reasonable to combine - systemic estrogen is minimally effective for GSM and there are no risks of combining with a vaginal estrogen due to negligible systemic absorption.
When is cyclic progestogen dosing recommended and why?
Causes a monthly withdrawal bleed. Useful during the menopause transition as helps reduce breakthrough bleeding.