HPV
WHICH GENOTYPES HAVE THE MAX ASSOCIATION WITH CERVICAL CANCER
What would you advise someone who has had their first smear showing hrHPV positive and negative cytology
Repeat smear in 12 months time
What is the swede score that will prompt high suspicion of CIN2 + disease
8-10
WHAT ARE THE TWO ONCOGENIC PROTEINS THAT ARE OVEREXPRESSED IN HGCIN
E6 AND E7
Viral DNA integrates into the cell DNA and this results in overexpression of these oncoproteins which in turn disrupt normal cell control
What is the audit standard for seeing low grade referrals
99% seen within 6 weeks of referral
A patient has low grade smear, colposcopy is adequate and low grade, biopsy shows CIN 1, what is ur advice?
How many hr HPV strains does the nonavalent vaccine protect against? what are they?
7 strains 6, 18, 31, 33, 45, 52, 58
in the hrHPV positive negative cytology pathway, the third smear done is hr HPV negative, what will you advise?
discharge to routine recall
Patient has CIN1, worried because of PCB/IMB and wanting treatment, what will you advice
Reassure as along as adequate colposcopy and matching smear/biopsy. Look for other reasons
what is the incidence of CIN 2+ in hr HPV positive, negative cytology cohort
2-4%
urgent referral to colposcopy
When will you not advice conservative management of CIN2