Causes/risks
The inflammation of the stomach lining
What is gastritis?
Increased rates of this cellular process contribute to cell proliferation and cancer growth
What is mitosis?
This cancer critical gene undergoes a gain in function
What is a proto-oncogene?
This activity causes a 60-70% higher risk of developing gastric cancer
What is smoking?
This process of building new blood vessels that aids in tumour growth
What is angiogenesis?
A state of permanent irreversible cell cycle arrest, where cells stop dividing but don't die
What is cellular senescence?
Pernicious anemia causes a decrease in this bacteria-killing fluid
What is stomach acid?
When gastric cells move through the basement membrane into deeper tissues
What is invasion?
This tumour suppressor gene shares it name with a rare, fast-growing eye cancer
What is Retinoblastoma?
This bacteria is known to lead to most non-cardia gastric cancers
Loss of this glycoprotein leads to loss of cell to cell adhesion
What is e-cadherin?
The hypothesis that tumour suppressor genes require both alleles to be inactivated to cause loss of function, and thus cancer
What is the two-hit hypothesis?