Brain
What is the main opioid receptor involved in opioid highs?
mu receptor (MOR)
What is a disease that commonly occurs in people that use opioids?
Hepatitis B and C
Name the two major nerve networks in the GI tract
Submucosal and myenteric plexuses
What is one effect of opioids?
euphoria, relaxation, slowed breathing, faster heart rate, jitters, anxiety
Name one opioid that is metabolized in the liver through the P450 system?
Fentanyl, Oxycodone, Tramadol
What is one effect of activated opioid receptors in the stomach?
slower movement, tightening of the pylorus and antrum, less hyperpolarization
What is dopamine actually responsible for?
Recognizes something as rewarding
What could contribute to or worsen liver injury as a result of using opioids?
Lipid oxidation, Mitochondrial oxidative injury
What are the two receptors that are most responsible for nerve activity in the gut?
Mu and Delta opioid receptors