Drugs
Blood Product
Onc Trials
Misc
General Knowledge/Fun
100
SLAMF7 inhibitor
Elotuzumab
100
Shelf life of pRBC if refrigerated
42 days
based on redcross data
100
Gem Cis Durva vs Gem Cis in biliary tract cancer
Topaz-1 trial
OS 12.8 m vs 11.5 m (p=0.021)
100
55 year old male admitted for sob, and cough, found to have 3.5 cm RUL mass, for which he underwent bronchoscopic biopsy. RUL mass biopsy was positive for adenocarcinoma, so were 4R and level 7 lymph nodes. What stage of NSCLC the patient has?
Stage IIIA
100
First US President
President George Washington (April 30, 1789 he took oath from balcony of Federal Hall on Wall Street, NY)
200
Abiraterone
inhibits 17α-hydroxylase/C17,20-lyase (CYP17)
200
Are platelets refrigerated for storage?
Shelf Life: 5 days
Storage Conditions: Room temperature with constant agitation to prevent clumping
200
Alex
Alectinib vs. Crizotinib in ALK pos NSCLC
– Rate of disease progression or death: Alectinib group: 41% vs Crizotinib group: 68% (P<0.001)
– Grade 3 to 5 adverse events: Alectinib group: 41% vs Crizotinib group: 50%
No OS benefit as of now, but was seen more to benefit patients with brain mets at presentation.
200
CASGEVY™ (exagamglogene autotemcel [exa-cel]) is approved in which conditions?
CRISPR/Cas9 gene-edited cell therapy.
Patient’s own hematopoietic stem and progenitor cells are edited at the erythroid specific enhancer region of the BCL11A gene through a precise double-strand break. This edit results in the production of high levels of fetal hemoglobin (HbF; hemoglobin F) in red blood cells
Sickle cell and Transfusion dependent beta thalassemia.
200
Festivals of Syracuse: What was celebrated on May 5th
Cinco De Mayo
Upstate Orthopedics Mountain Goat Run 10 mile marathon
300
Caplacizumab
anti-von Willebrand factor humanized immunoglobulin, targeting A1-domain of vWF, inhibiting the interaction between vWF and platelets.
Hercules trial: Cablivi vs placebo
time to platelet normalization 2.69 d vs 2.88 d (p=0.01)
recurrence of TTP 12% vs 38% (p<0.001)
300
Shelf life of pRBC if frozen
10 years or more
based on redcross data
300
IMBrave150
Atez + Bev vs Sorafenib
OS 19.2 m vs 13.4 m (p<0.0001)
300
What drug was evaluated in Perseus Trial?
Dara-RVd (induction/consolidation) or Dara-Rd (maintenance)
300
In which city Declaration of Independence signed?
It was during second Continental Congress in 1774, in Philadelphia (then Capital of The USA till 1800), founders signed the Declaration of Independence.
400
Selective rearranged during transfection inhibitors
Selpercatinib (LIBRETTO-001 trial) and Pralsetinib (ARROW Trial)
400
When to use massive transfusion and what is Upstate massive transfusion protocol?
Indications:
– Transfusion of ≥10 u RBC in 24 hrs
– Transfusion of half of blood volume in 3 hours
– On-going blood loss 150 mL/min
Anytime bleeding is on-going and brisk such that:
– There is a high risk of rapid morbidity/mortality
– Blood products are required to be transfused at such a rapid rate that testing-directed transfusions and cross-matching are precluded
Protocol at Upstate 6:6:1 (pRBC:FFP:Platelets)
best outcomes with 1:1:1 (https://www.ncbi.nlm.nih.gov/books/NBK499929/)
400
Maintenance Olaparib vs. Placebo in pancreatic cancer
Polo trial
Should receive initial chemo with platinum
No OS benefit: 18.9 m vs 18.1 m (p=0.683)
PFS benefit: 7.4 m vs 3.8 m (p=0.0035)
400
Mechanism of Action of Lifileucel
It is first cancer TIL which gets FDA approval for melanoma.
Tumor Infiltrating Lymphocytes. In contrast to CAR-T, T cells are collected from the tumor. They are non engineered and expanded and returned back to the patient.
400
Best Picture Academy Award 2024
Oppenheimer
500
Emicizumab
humanized bispecific monoclonal antibody, binds to both the activated coagulation factor IX and to factor X, mediating the activation of the latter. This is normally the function of coagulation factor VIII, which is missing in hemophilia A.
500
Which of the following is not plasma derivatives:
Albumin, Immunoglobulins, Cryoprecipitate, Coagulation factor
Cryoprecipitate - It is plasma component and not derivative
500
Based on which trial we use FOLFIRINOX in pancreatic cancer?
What is trial based on which NALIRIFOX was approved as first line in pancreatic cancer?
Prodige-4/ACORD 11 trial
FOLFIRINOX vs Gem
OS 11.1 m vs 6.8 m (p<0.001)
PFS 6.4 m vs 3.3 m (p<0.001)
NAPOLI-3 trial
NALIRIFOX vs Gem Abraxane
OS 11.1 m vs 9.2 m (p=0.0355)
PFS 7.4 m vs 5.6 m (p<0.0001)
500
how many arms are there in stampede platform
A-L
500
Which Golden Globe Award-winning actor and producer has ties to Syracuse, NY
Tom Cruise, Born in Syracuse NY