PBMC
Metoprolol is:
a. An acid with a pKa of about 4
b. An acid with a pKa of about 9
c. A base with a pKa of about 4
d. A base with a pKa of about 9
d. A base with a pKa of about 9
What three first-dose vaccinations are important to receive at the 11-12 age bracket? (non annual)
HPV, MENACWY, TDaP.
A 48-year-old male is currently taking insulin for his diabetes. He moved from another country, so you do not have much information about him. He is presenting with shakiness and sweating.You immediately check his blood glucose level, which came out to be 62 mg/dL. What would be the most appropriate treatment for this patient?
A. administer a piece of chocolate
B. administer glucagon nasal powder
C. administer diet soda
D. administer 1 tablespoon of honey
D. administer 1 tablespoon of honey
What kind of pharmacy is Costco?
Mass Merchant
Whether or not a study can be generalized to a larger population is based on what sort of validity?
External
The docking protein in insulin receptor signaling is
A. Akt
B. Grb2
C. PI3K
D. IRS
D. IRS
Using the Lipinski Rule of Five, aciclovir has how many hydrogen bond donors and acceptors?
8 hydrogen bond acceptors and 4 hydrogen bond donors
What is the maximum single dose of Epinephrine for adverse reactions?
0.5 mg
TJ is a 46-year-old man with a BMI of 32 and has a sedentary lifestyle. His A1c last year was 5.8%. How frequently should this man’s A1c be checked?
A. every 6 months
B. every year
C. every 2 years
D. every 3 years
B. every year
A pharmacy with 2 pharmacists can have how many technicians?
3
Which section of a study would the following excerpt come from?
The trial was a multinational, 3-phase, double blind, randomized trial that extended 24 weeks.
Methods
Which one of the following is the death signal released in the intrinsic apoptotic pathway?
A. Fas (CD95)
B. cytochrome c
C. caspase-8
D. caspase-3
B. cytochrome c
Compared to metoprolol, sotalol has lower permeability in the intestine (Table 1) because:
a. Sotalol is more hydrophobic than metoprolol
b. Sotalol is a weaker acid than metoprolol
c. Sotalol has more hydrogen bond acceptors and donors than metoprolol
d. Sotalol has a higher LogP than metoprolol
c. Sotalol has more hydrogen bond acceptors and donors than metoprolol
A patient comes into your pharmacy and says, “I can’t sleep because of this crazy pressure in my nose and forehead. I can’t relax or do anything that I need to get done." What is their chief complaint?
The pressure in the nose and forehead.
(This is answered by asking what brings you into the pharmacy, and is the thing we can directly help with.)
A 40-year-old person is here for a pharmacy clinic. While reviewing the patient’s chart, you discover that this person has dyslipidemia and diabetes, taking insulin and statin therapy. The office blood pressure today was 132/78 mmHg, and historically has been between SBP of 130 and 135 at the office. These blood pressure values have been confirmed with the patient’s home blood pressure values. Which of the following blood pressure categories should you identify this person with?
A. normotension
B. stage 1 hypertension
C. stage 2 hypertension
D. stage 3 hypertension
B. stage 1 hypertension
Is this DEA number valid? EB7344195
no
A pain scale from 1-10 would be categorized under what sort of data?
Ordinal
Transfer of pyruvate to mitochondria is accomplished by one of the following carriers:
A. MCT
B. TIM22
C. TOM40
D. MPC
D. MPC
The structure of ketoprofen explains its reduced permeability at higher pH (Figure 1) because:
a. The main form of ketoprofen has a negative charge at pH 8 and is neutral at pH 3
b. The main form of ketoprofen has a positive charge at pH 8 and is neutral at pH 3
c. The main form of ketoprofen is neutral at pH 8 and has a negative charge at pH 3
d. The main form of ketoprofen is neutral at pH 8 and has a positive charge at pH 3
a. The main form of ketoprofen has a negative charge at pH 8 and is neutral at pH 3
Is this prescription missing anything?
“Acetaminophen 325g. Take 1-2 tablets q4-6h prn, DNE 4g a day.”
Route, by mouth
A patient is taking a medication for T2DM. This patient is complaining of frequent urinary tract infections. Name two generic medications that you suspect would cause the patient’s complaint?
SGLT2 Inhibitors: canagliflozin, dapagliflozin, empagliflozin, ertugliflozin, and bexagliflozin
A patient just purchased a box of Pseudoephedrine, with 20 120mg tablets inside. Could they purchase any more pseudoephedrine today?
Yes, if there is a box size with 1.2 g inside.
A study that looks at current patients with lung cancer and makes note of those who have parents who are smokers would describe what kind of trial design?
Observational Case Control
Synaptic Signaling is an example of
A. contact-dependent signaling
B. paracrine signaling
C. neurotransmission
D. endocrine signaling
B. paracrine signaling
Based only on the pH, permeability of metoprolol in the duodenum compared to that in the proximal jejunum (Table 1) should be:
a. Less than 3.7x10-5 cm/s because more metoprolol is positively charged in the duodenum
b. Less than 3.7x10-5 cm/s because more metoprolol is neutral in the duodenum
c. More than 3.7 x10-5 cm/s because more metoprolol is positively charged in the duodenum
d. More than 3.7 x10-5 cm/s because more metoprolol is neutral in the duodenum
a. Less than 3.7x10-5 cm/s because more metoprolol is positively charged in the duodenum
What are the heart rates for the following categories?
Bradycardia:
Normal:
Tachycardia:
Bradycardia: <60 bpm
Normal: 60-100 bpm
Tachycardia: >100 bpm
2 mg pitavastatin has the same lipid lowering potency as what strength of pravastatin?
2 mg Pitavastatin ~ 4 mg Pravastatin
What are the 3 strategies that can be used to prevent medication errors with Look-Alike, Sound-Alike Medications?
Include both brand and generic names on prescriptions and labels
Include the indication of the medication in the prescriptions or order
Draw visual attention to LASA risk in medication storage contains
If my study, that looks at metformin’s ability to lower blood glucose, has a p-value of <0.05, what does this mean?
There is less than a 5 percent chance that the difference within the study is due to chance.
The one-electron reduction of oxygen leads to the formation of
A. H2O2
B. O2.–
C. HO.
D. H2O
B. O2.–
The data in Figure 2 for inhibition of hPEPT1 show that:
a. Valaciclovir has an IC50 of about 1 mM and is a stronger inhibitor than glibenclamide
b. Valaciclovir has an IC50 of about 10 mM and is a stronger inhibitor than glibenclamide
c. Valaciclovir has an IC50 of about 1 mM and is a weaker inhibitor than glibenclamide
d. Valaciclovir has an IC50 of about 10 mM and is a weaker inhibitor than glibenclamide
c. Valaciclovir has an IC50 of about 1 mM and is a weaker inhibitor than glibenclamide
What is the medical term/condition that is characterized by loss of muscle mass, strength, and function as a result of age?
Sarcopenia
A 72-year-old woman with a history of frequent vomiting presents with weakness and dizziness.
ABG: pH 7.50 / paCO2 47 mmHg / HCO3- 32 mEq/L
Electrolytes: Na+: 138 mEq/L, Cl-: 88 mEq/L
What is the most likely primary acid-base disturbance?
Metabolic alkalosis
In a hospital setting, what is the general stop date for Opioids?
7 days
Provide 2 examples of a threat to internal validity.
Drop-out bias
history bias
selection bias
maturation
instrumentation
experimenter bias
testing
statistical regression
confounding
placebo effect
Which one of the following enzymes remove H2O2 in a glutathione (GSH)-dependent manner?
A. SOD1
B. GPx
C. Prx
D. SOD3
B. GPx
Valaciclovir is a substrate of hPEPT1 and a prodrug of Aciclovir. Mechanistically, this suggests that:
a. The ether in valaciclovir is cleaved in the gut lumen before absorption via hPEPT1
b. The ether in valaciclovir is cleaved in the enterocytes or plasma after absorption via hPEPT1
c. The ester in valaciclovir is cleaved in the gut lumen before absorption via hPEPT1
d. The ester in valaciclovir is cleaved in the enterocytes or plasma after absorption via hPEPT1
d. The ester in valaciclovir is cleaved in the enterocytes or plasma after absorption via hPEPT1
Which of the following vaccines are indicated in pregnancy?
Boostrix, Adacel, FluMist, Fluzone, Varivax, Priorix, Abrysvo, Arexvy, Shingrix
Boostrix, Adacel, Fluzone, Abrysvo
Patient GG is a 45 year old male who arrives at your clinic requesting a blood pressure check. His blood pressure is 136/80 mmHG, he has no history of clinical CVD, and his PREVENT score is 6.5%. GG reports no other health conditions. What course of treatment do you recommend for this patient?
Lifestyle intervention and request that the patient come back for a recheck after 3-6 months.
If SBP is still ≥ 130 mmHg or DBP ≥ 80 mmHg after they come back for a recheck, then initiate antihypertensive medications
Give 2 examples of an “off-line” pharmacist.
Antibiotic stewardship pharmacist
Clinical coordinator
Controlled substance pharmacist
Informatics pharmacist
Investigational drug pharmacist
Transition of care pharmacist
Transplant pharmacist
A double blind randomized controlled trial was conducted using 500 participants to investigate whether daily vitamin D intake reduces the incidence of advanced cancer. Interpret the results of the following test for statistical significance:
RR = 0.92, 95% CI of 0.71-1.14
Vitamin D group had a lower risk for advanced cancer, but the results are statistically insignificant since the 95% CI includes 1
The sympathetic stimulation in chronic exercise leads to
A. phosphorylation of iNOS and increase NO production
B. decrease in nitric oxide bioavailability as nitrosothiols
C. activation of the b3Gs receptor and cardioprotection
D. activation of nNOS by a b1Gq receptor
C. activation of the b3Gs receptor and cardioprotection