Stem Cell Fundamentals
Mechanisms of Stem Cell Aging
Regeneration & Stem Cell Exhaustion
100

This process allows stem cells to develop into specialized cell types.

What is differentiation?

100

Which tumor suppressor protein mediates cell-cycle arrest following the telomere-associated DNA damage response?

What is p53?

100

This tissue replaces its lining approximately every 4 to 5 days.

What is the gut lining?

200

This process allows stem cells to produce more stem cells.

What is self-renewal?

200

This term describes the surrounding environment that regulates stem cell behaviour and changes with age.

What is the stem cell niche?

200

These stem cells are activated following injury to support skeletal muscle regeneration

What are satellite cells?

300

This is the resting state in which adult stem cells spend most of their time.

What is quiescence?

300

This cellular process, listed as defective during aging, is responsible for removing damaged mitochondria.

What is mitophagy?

300

These stem cells produce blood and immune cells.

What are hematopoietic stem cells?