Wound Healing
Heals the wound from the edges of the margins inward
What is Granulation tissue?
excessive shrinkage of the healing tissue
What is a contracture?
Contusion
What occurs when a sudden, heavy compressive force occurs in a muscle from a direct blow?
Leads to local degenerative arthritis
What is the result of the lack of vascularization and impeded inflammatory response for cartilage?
The rapid increase (endothelial cells) beginning within 2 days-- Wound contracts , myofibroblasts cause shrinking of the edges
Formation of scab – eventually removed by macrophages
What is proliferation?
Prolonged immobilization, Infection, Graft malposition after ligament reconstruction
What is contracted tissue with excessive arthrofibrosis caused by?
Strain
What occurs when tensile forces at a myotendinous junction, leads to overstraining of muscle fibers?
hemorrhage, hypertrophy, and hyperplasia of the synovial lining cells and mild chronic inflammation
What is the results of injury to the synovial membrane?
budding of capillaries
What is neovascularization?
Inhalation of asbestos leading to restrictive lung disease
What is the agent and result of a damaged basement membrane and fibrosis and scarring in the lung?
Eccentric contraction injury
What type of contraction can cause a strain in a muscle?
The demolition crew / macrophages
What is the function of osteoclasts?
Scar is reduced and coloring starts to return to normal
This phase can take years
What is the Remodeling and maturation phase?
approximation and maintenance of the neurotubules
What is the most important factor in a successful nerve regeneration after a repair.
compromised biomechanical integrity with increased minor collagens,
cellularly decreased collagen cross-links and breakdown with decreased strength & elasticity
What cellular and biomechanical effect occurs in a tendon if the injury is healed with scar tissue?
produce bone matrix and initial bone mineralization and osteoclasts reabsorb bone.
What are osteoblasts function?
composition of abnormal or keloid scars
What is type lll collagen?
myelin degeneration and axonal fragmentation
What occurs when the peripheral portion of a nerve is cut?
The outer layer- strong collagen fibers- stabilizer
What is the annulus of a spinal disc and its cellular composition and function?
Osteocytes
What bone cell detects local mechanical loading and send signals to the surface osteoblasts to initiate bone remodeling?