CNS drugs
Alpha ANS
How drugs get down PK/PD?
Adverse effects/contraindications
beta ANS
100

This drug is a nicotinic & muscarinic agonist

Carbancol

100

This adrenergic receptor causes vasoconstriction & acts on Gq

Alpha 1

100

A route of administration resulting in 100% bioavailability

intravenous 

100

This alpha 1 agonist causes headache, vomiting & hypertension

Methoxamine

100

Drug treats navicular disease & laminitis

Isoxsuprine

200

This stimulates the release of ACh into the synaptic cleft

Black widow spider toxin

200

This drug used to reverse effects of only xylazine in large animals

Tolazoline

200

This increases drug metabolism & decreases therapeutic effect

Liver Enzyme induction

200

This beta 2 agonist causes locomotion disorder, bloat, anorexia

Ractopamine

200

Reversal for Xylazine & detomidine

Yohimbine

300

This is the main indication of Edrophonium

Diagnosis of Myasthenia Gravis

300

This is a non-selective beta blocker used in wide angle glaucoma to reduce intraocular pressure

Timolol

300

Acts on one receptor but may produce multiple effects

Selective Drug

300

This cholinergic agonist should only be used when no GI obstruction is present 

Bethanechol

300

This drug is an antiarrhythmic in dogs

Sotalol

400

Pralidoxime is indicated for treatment of ___ but contraindicated in ____

Organophosphate poisoning 

Carbonate poisoning 

400

This is the therapeutic use of dopamine

Treatment of cardiogenic & septic shock

400

This requires 4-5 half lives in order to reach what?

Steady State concenetration

400

This is banned in food producing animals

Clenbuterol

500

The mechanism of action of irreversible cholinesterase inhibitors 

Irreverisbly phosphorylate the esteratic site of AChE & pseudocholinesterase

500

These are 3 therapeutic uses of epinephrine (there are more than 3)

Relieve respiratory distress due to bronchospasm

Hypotension 

Cardiac arrest; partial or complete AV block

Rapid relief from hypersensitivity rxns

Prolongs the action of local anesthetic drugs

Topical hemostatic

500

A competitive antagonist will _______ efficacy & _______ potency 

do nothing to efficacy & decrease potency

500

This drug is contraindicated in patients with CHF (congestive heat failure)

Isoproterenol (questionable?)