Leaving Group Therapy
It's not a phase, it's a blight
Lost MMR and My Will To Live
Cell Out
HOUSTON, WE HAVE ANSWERS
100

This pericyclic reaction converts a 1,3,5-hexatriene to a cyclohexadiene via a disrotatory 6π-electron electrocyclic ring closure under thermal conditions.

What is a thermal electrocyclic reaction governed by the Woodward–Hoffmann rules?

100

This oomycete genus — not a true fungus — caused the Irish Potato Famine and reproduces via motile, biflagellate zoospores. Its mating types A1 and A2 must both be present for sexual oospore formation.

What is Phytophthora infestans?

100

Roshan's Aegis of the Immortal expires after this many minutes if not triggered, healing the holder to full HP and mana.

What is 5 minutes

100

This enzyme unwinds the double helix ahead of the replication fork, breaking hydrogen bonds between complementary base pairs.

What is helicase?

100

This boundary marks the distance at which a celestial body's tidal forces overcome the gravitational self-cohesion of an orbiting fluid satellite, causing it to disintegrate.

What is the Roche Limit?
200

In the Barton reaction, this radical intermediate — formed by δ-hydrogen abstraction via a six-membered transition state after photolytic N–O homolysis of a nitrite ester — goes on to form a δ-nitroso alcohol.

What is an alkoxy radical?

200

Crown gall disease works because Agrobacterium tumefaciens transfers this specific segment of its Ti plasmid into the host plant genome, hijacking the plant's own transcriptional machinery to produce opines the bacterium metabolizes.

What is T-DNA (transfer DNA)?

200

Added in 7.36, these hero-specific pregame choices let one hero lean into different matchups and playstyles.

What are facets?

200

In eukaryotic transcription, this multi-subunit complex phosphorylates the C-terminal domain of RNA Polymerase II at Serine 5, enabling promoter clearance.

What is TFIIH?


200

In the Hertzsprung-Russell diagram, stars in this evolutionary phase have exhausted core hydrogen and begun shell hydrogen burning, causing them to expand and cool as they cross the subgiant branch.

What is the red giant branch (RGB)?

300

The Paternò–Büchi reaction between an aldehyde and an electron-rich alkene preferentially gives this regiochemical and stereochemical outcome for the oxetane product, explained by the Griesbeck rule and triplet 1,4-diradical stability.

What is the more substituted (head-to-head) oxetane with endo selectivity (the bulkier group cis to the alkyl on the carbonyl)?

300

In the gene-for-gene model proposed by Flor, a plant's resistance (R) gene product recognizes a pathogen's corresponding avirulence (Avr) protein, triggering this rapid, localized programmed cell death response that starves biotrophic pathogens of living tissue.

What is the hypersensitive response (HR)?

300

On Invoker’s talent tree, this is the spell that gets a radial version at level 25.

What is Deafening Blast?

300

This quality-control pathway degrades mRNAs that contain a premature termination codon, preventing production of truncated and potentially dominant-negative proteins.

What is nonsense-mediated mRNA decay (NMD)?

300

This relativistic effect, confirmed by Gravity Probe B, describes the dragging of local inertial frames around a rotating massive body, causing a precession of orbiting gyroscopes perpendicular to the geodetic effect.

What is frame-dragging (or the Lense-Thirring effect)?

400

In the Matteson homologation, an α-haloboronate ester undergoes 1,2-migration with inversion at carbon. This chiral auxiliary on boron — derived from a C₂-symmetric diol — controls the absolute stereochemistry of the newly formed C–B bond with >99% ee.

What is pinanediol (or (+)-pinanediol)?

400

Citrus greening (Huanglongbing) is caused by this phloem-limited, gram-negative alphaproteobacterium vectored by the Asian citrus psyllid. It remains unculturable in artificial media, which has severely hampered Koch's postulates confirmation and therapeutic research.

What is Candidatus Liberibacter asiaticus?

400

Whenever an enemy hero dies nearby, this hero can create a money tree that drops gold bags to collect.

Who is Nature’s Prophet?

400

During V(D)J recombination, these two lymphoid-specific proteins recognize and cleave recombination signal sequences to generate antigen receptor diversity.

What are RAG1 and RAG2?

400

In neutron star interiors, beyond nuclear saturation density, matter may transition into this hypothesized phase in which quarks are no longer confined within individual hadrons, potentially forming a stable "strange" variant.

What is quark matter (or quark-gluon plasma / strange quark matter)?

500

The Corey–Bakshi–Shibata (CBS) catalyst achieves enantioselective ketone reduction by simultaneously activating BH₃ as the reductant and coordinating the ketone carbonyl. The oxazaborolidine ring's chirality is ultimately derived from this amino acid.

What is proline (specifically (S)-diphenylprolinol)?

500

Dutch elm disease fungi (Ophiostoma spp.) spread systemically through this specific tissue type, where tyloses formed by adjacent parenchyma cells attempt to wall off the infection — but in susceptible cultivars, the resulting vascular occlusion ultimately kills the tree faster than the fungus alone would.

What are xylem vessels?

500

This hero’s innate ability is Switch Discipline, which swaps between a Kazurai Katana and Shodo Sai.

Who is Kez?

500

In the integrated stress response, phosphorylation of eIF2α paradoxically increases translation of this transcription factor via upstream open reading frames in its 5′ UTR, activating genes involved in amino acid metabolism and autophagy.

What is ATF4?

500

This tensor equation from general relativity equates spacetime curvature on the left-hand side with the stress-energy content on the right, and its linearized, weak-field solutions predict the gravitational wave polarizations h+ and h×.

What are the Einstein field equations?