Week 13
Ribonucleoprotein complex that translocates nascent membrane and secretory proteins to the endoplasmic reticulum
What is the Signal Recognition Particle (SRP)?
Small, membrane-bound organelles found in almost all eukaryotic cells
What is peroxisomes?
Lysosomal maturation begins when the Golgi packages hydrolytic enzymes into vesicles called these, which bud off and fuse with early endosomes.
What are clathrin-coated vesicles?
Can be recycled locally after exocytosis
What is Synaptic Vesicles?
Occurs while the protein is being synthesized by ribosomes.
What is co-translational?
The nuclear pore complex is made up of proteins called these, of which there are approximately 30 different types that together form the full pore structure.
What are nucleoporins?
A protein that forms a lattice-like, polyhedral coat on the cytoplasmic face of membranes, essential for forming coated vesicles during endocytosis and intracellular trafficking
What is clathrin?
Neurotransmitters are actively pumped into synaptic vesicles against their concentration gradient by these membrane proteins, using the proton gradient generated by the V-ATPase as an energy source.
What are vesicular neurotransmitter transporters?
Proteins destined for this organelle are imported post-translationally using a signal sequence recognized by the TOM complex on its outer membrane, which threads the protein through to the matrix.
What is the mitochondria?
An ER protein that phosphorylates itself and triggers the upregulation of ER chaperone protein expression in response to excessive misfolded proteins
What is IRE1?
Oligosaccharide chains attached to proteins are processed in this organelle.
What is the Golgi apparatus?
A mostly positively charged peptide sequence, Proline-Lysine-Lysine-Lysine-Arginine-Lysine-Valine, located at the N-terminus
What is the nuclear localization signal of T-antigen?