What do you mean? I
What do you mean? II
Give me the opposite of... I
What do you mean? III
Give me the opposite of... II
100

"This reading is mandatory"

It is required, obligatory, you have to do this reading. 

100

"Do you concur?"

Do you agree? 

100
"This is completely off topic"

This is relevant. 

100

"Do you want this order ready by 4 tomorrow? It's feasible!"

I can do it

100

"Oh that was implied"

"That was explicitly said/explicit"

200

"Wow, it is the epitome of elegance!"

It is a perfect example of elegance. 

200

"It was rife with cockroaches, ew!"

It was full of cockroaches and cockroaches are disgusting.

200

"This is a inane question"

"This is a brilliant question"

200
"Her bedroom was immaculate"

Her bedroom was extremely clean. 

200

"I condone this behavior"

I reject this behavior and will not let it happen. 

300

"I avoid him because he's a contentious guy"

He is likely to cause an argument

300

Two tests, an X-ray of the lungs, and the paucity of symptoms proved it.
—Richard Brookhiser, National Review, 1 Dec. 2022

smallness of number/quantity

300

"It was obvious she was trying to deceive me"

It was obvious she was tring to ve honest/frank with me

300

"He's such an idiot, I cannot believe somebody can be that oblivious"

He doesn't see what is going on in front of/around him. 

300

"The Real Madrid is precluding this player's transfer to Manchester United"

The Real Madrid is letting this player transfer to Manchester United

400
"Can someone read the previous meeting's minutes, please?"

Can someone read the official records/proceedings of the previous meeting? 

400

"He wanted to implicate me in the crime!"

He was trying to show that I did commit the crime

400

"I am ambivalent feelings about it"

I am quite sure about it

400

"I saw her at the supermarket, she was shopping incognito"

I recognized her but she was trying to hide who she was. 

400

"They scrutinized her every moves"

They did not really pay attention to her. 

500
"She was indignant about the verdict"

She was angry/frustrated about the verdict

500

"He was a contemporary of Mozart!"

He lived at the same time as Mozart. 

500

"He's trying to hinder my work!"

He is trying to assist me/help with my work 

500

"Don't want to be rude but his outfit is pretty incongruous"

He is dressed with mismatched items of clothing (like clown shoes and a dress suit) 

500

"I have been pondering it for a while actually..."

I have not been thinking about it at all.