Cytokines!
Dendritic Cells and Wannabes
Name that Lymphocyte
Naive, Effector, or Memory
Viral Olympic Moments
100
This cytokine is produced by macrophages, fibroblasts and endothelial cells to induce production of granulocytes.
What is GM-CSF or G-CSF?
100
This type of DC produces large amounts of Type I IFN to promote an antiviral response, often mediated by TLR7 and TLR 9.
What are Plasmacytoid Dendritic Cells?
100
These cells express MHC Class II and CD19 and are the largest subtype of their group.
What are follicular B cells?
100
This CD3+ cell expresses low levels of CD25 and CD44 and high levels of CD26L, CD127, CCR7, and CD45RA.
What is a naive T cell?
100
Yusuf Dikec, who represented this country, earned comparisons to John Wick as he won a silver medal in the 10m air pistol mixed event.
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What is Turkiye?
200
This cytokine is produced by bone marrow stromal cells to induce differentiation of hematopoietic stem cells.
What is stem cell factor or c-KIT ligand?
200
This type of DC, derived from the embryonic fetal liver and yolk sac, are typically found in the epidermis.
What are Langerhans cells?
200
These cells are CD3+, CD25+, and FOXP3+.
What are regulatory T cells?
200
This CD20+ cell expresses membrane IgM and IgD with high expression of CXCR5 and low expression of CD27.
What is a naive B cell?
200
This Australian introduced creative moves to the new Olympic breaking competition, some of which were dubbed the kangaroo.
Who is B-girl Raygun or Dr. Rachael Gunn?
300
This cytokine is produced by fibroblasts and bone marrow stromal cells to induce T-cell maturation.
What is IL-7?
300
While these cells are often confused for DC’s due to their morphology, they do not present antigen to T cells are are essentially in B cell activation in germinal centers.
What are follicular dendritic cells?
300
These cells primarily express CD27 and IgM but have limited specificity.
What are marginal zone B cells?
300
This large CD20+ cell with increased cytoplasm secretes IgG, IgA, or IgE with low CXCR5 expression and high CD27 expression.
What is an activated or effector B cells?
300
Name these 3 medalists from the women's gymnastics floor final.
Who are Rebecca Andrade, Simone Biles, and Jordan Chiles?
400
This cytokine is produced by T-cells and induces maturation of all immature progenitors.
What is IL-3?
400
This subset of dendritic cells is the most numerous type of DC and is able to capture exogenous antigen to induce CD4+ T cell responses.
What are Classical or Conventional Dentridic Cells 2 (cDC2)?
400
These cells are CD3+ with variable CD4 and CD8 expression with limited specificity.
What are gamma delta T cells?
400
This CD3+ cell expresses low levels of IL-2R, high levels of L-selectin and IL-7R, and is CD45RO+.
What is a memory T cell?
400
Snoop Dogg described maneuvers in this event, his new favorite, to Martha Stewart as "We call that swerving in the hood, lane to lane" and to Kevin Hart as "horse crip walking."
What is dressage?
500
This cytokine is produced by bone marrow stromal cells to induce production of classical and plasmacytoid DC’s and B cells.
What is FLT-3 ligand?
500
These DC’s are similar to classical DC’s but express CD11b and CCR2 in addition to CD11c.
What are Monocyte-derived dendritic cells?
500
These cells are CD3+, CD16+, and CD56+ with expression for glycolipid-CD1 complexes.
What are NKT cells?
500
This CD3+ cell expresses high levels of CD25 and integrins, low levels of CD62L, CCR7, and CD127, and is CD45RO+.
What is an effector T cell?
500
This pommel horse specialist helped lead the US Men's Olympic team to their first medal in 16 years.
Who is Stephen Nedoroscik?