Adaptive Immune System
What are Immunoglobulins
Synthesized by B-cells and plasma and secreted by plasma
When do Immunoglobulin rearrangements occur
Early in B-Cell precursor development
In CD3 how many polypeptides are associated with the TCR
6
What chromosomes are T-cell receptor gene clusters found on
Chromosomes 14 and 7
Which immunoglobulin is secreted as a pentamer
IgM
What is FaB
Epitope binding region
What are the variable regions in light chains
Rearrangement of V and J
What do each TCR polypeptide chain contain
variable and constant region domain
What are the two levels of T cell diversity
First level is the Random rearrangement of V (D) J genes through deletion and inversion
Second level of diversity occurs with TdT transferase which creates junctional diversity
T-cell receptors can bind
Peptides presented on MHC
What are the 5 isotypes
IgM, IgD, IgG, IgA, IgE
Heavy Chains are facilitated by
VDJ recombinase
What interacts with pMHC
Complementarity-determining regions (CDRs)
Uniting variable an constant regions occur at the
mRNA level
What is somatic hypermutation
Point mutations in B cells
Leads to affinity maturation (stronger binding)
What two Isotypes have a J chain
IgM, IgA
Antigen binding variability is determined by
Random combinations
What are the three DNA rearrangements in TCR
Deletions, Inversions, and Junctional diversity
What are the Isotype mediate function
Activation of complement
Secretion into mucus membranes
Bound to surface of cells
Which immunoglobulin is most abundant in circulation?
IgG
What two isotypes are in the Classical Pathway
What do unstimulated B-cells display
Monomeric IgM or IgD
T cell receptors do not undergo what
Subsequent changes like immunoglobulin genes
What Isotypes role is unclear
IgD
Which are functions of IgG?
Opsonization
Neutralization
Cross placenta
Activate complement