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ADDICTION
EFFECTS ON THE BRAIN
DRUGS FOR DRUGS
ALCOHOL
COMORBIDITY
100
It f***s up your life and you can't stop
What is Leon Rappaport's definition of addiction?
100
A substance that promotes activity of an NT
What is an agonist?
100
Replacing one drug for another
What is not the goal of Rx drug treatment for addiction?
100
The liver enzyme that is associated with alcohol's negative effects, and is produced in varying amounts depending on gender and ethnicity
What is ALDH (acetaldyhyde dehydrogenase)?
100
This is when two conditions co-exist in the same person
What is co-occurring/comorbidity?
200
A chronic, relapsing brain disease that is characterized by compulstive drug seeking and use, despite harmful consequences
What is NIDA's definition of addiction?
200
A substance that reduces action of an NT
What is an antagonist?
200
Block reinforcement, make use aversive, curb craving/prevent relapse
What are possible goals of Rx drug treatment for addiction?
200
GABA and Glutamate
What are the major NTs affected by alcohol?
200
Once both disorders are present, the two conditions contribute to one another over time; symptoms of both worsen
What is the reciprocal causation model?
300
Self-induced changes in neurotransmission that result in problem behaviors
What is Milkman & Sunderwitrth's definition of addiction?
300
NT Production, NT Storage, NT Release, Receptors, Reuptake & Enzymatic Degradation
What are the five areas agonists and antagonists can affect?
300
A well known drug that causes adverse effects if one continues to drink alcohol while taking it
What is Antabuse/Disulfiram?
300
The only Amendment in the Constitution that repeals a previous Amendment
What is the 21st Amendment?
300
The existence of these indicate a higher probability of having or developing a co-occurring substance abuse disorder
What are mood disorders?
400
Tolerance, withdrawal, failure to fulfill major obligations, continued use despite negative consequences, continued use despite knowledge of problems, unsuccessful attempts to control usage, usage beyond intended amount or frequency, etc.
What are criteria for substance abuse disorder?
400
The gap between neurons where synaptic transmission takes place
What is the Synaptic Cleft?
400
An injectable opioid agonist
What is Vivitrol and Naltrexone?
400
FAS, pFAS, ARBD, and ARND
What are Fetal Alcohol Spectrum Disorders?
400
This age group has the highest risk of developing a substance abuse disorder
Who are adolescents?
500
Satiation, arousal, and fantasy
What are the three motivations for addiction?
500
The pathway from 5-HT to DA
What is the Reward Cascade?
500
A leading researcher of addiction vaccines
Who is Dr. Kim Janda?
500
This is considered to be 1-2 drinks/day for men, and 1 or fewer drinks/day for women
What is moderate alcohol consumption?
500
These three externalizing disorders increase the probability of having or developing co-occurring substance abuse disorder, especially among teens
What are Conduct Disorder, ADHD, and Oppositional Defiant Disorder?