Basics
This term refers to the smallest quantity that can be weighed on a balance with a known sensitivity to maintain a desired level of accuracy
LWQ (Least Weighable Quantity)
This auxiliary label must be used when dispensing a compounded suppositories.
For rectal use only
This chapter sets the standard for sterile compounding.
USP <797>
This is the primary federal agency responsible for the approval and regulation of all animal drugs in the United States.
FDA
How many grams of active ingredient are in 250 mL of a 4% (w/v) solution?
10 grams
4g/100mL = x g/250mL; x = 10g
This term is known as a compounding recipe.
MFR (Master Formulation Record)
This organization maintains and publishes the list of drugs that are hazardous to personnel
NIOSH
Hands must be washed for at least this long.
30 seconds
True or False: Cost reduction is a legitimate reason for compounding a commercially available medication for a veterinary patient.
False
(It is generally not a legitimate reason for compounding human or veterinary drugs when a suitable FDA-approved product is available).
A dry powder has instructions to add 84 mL of sterile water to make a total final volume of 100 mL of solution. What is the powder volume?
16 mL
This is the mixing technique used to ensure potent APIs are uniformly distributed throughout a powder mix by starting with the smallest ingredient and gradually adding approximately equal volume of other ingredient(s).
Geometric dilution
This is water type that must be used in a nonsterile compounded preparation when the type of water is not specified in the prescription.
Purified water USP
Gloves must be disinfected with this before compounding.
70% IPA
True of false: Compounding animal
drugs using bulk drug substances violates the FD&C Act.
True
The Rx reads:
Azithromycin suspension 40 mg/mL
Ora-Blend qs ad 200 mL
If you have 500 mg azithromycin tablets available, how many whole tablets are needed to compound this prescription?
16 (40 mg/ml x 200 mL/500 mg)
This compounding technique involves using a small amount of a compatible liquid to grind an insoluble solid into a smooth paste, often on an ointment slab.
Levigation
The functional role of steviol glycosides in an oral liquid preparation.
Sweetener
This is the proper distance inside the hood where compounding should occur.
6 in from the edge
True or false: NSAIDs are generally safe for use in veterinary compounding.
False
A pharmacy needs to prepare 120 grams of a 3.75% hydrocortisone ointment using an ointment base (0% hydrocortisone) and a 10% hydrocortisone ointment. Using the alligation method, how many grams of the 10% ointment are needed?
45 grams
(3.75 parts of 10% needed from alligation, out of 10 total parts).
You are compounding a non-aqueous nonsterile ointment from bulk ingredients with no stability data available. According to USP <795>, the BUD should be no more than this period.
6 months (or the earliest expiration date of any single ingredient).
This is a common technique used to compound lollipops
Molding
This integrity test must be performed to confirm that the membrane filter has no leaks.
Bubble Point Test
A 6-year-old dog weighing 26 lb eats 5 pieces of sugar-free gum, each containing 1 g of xylitol with known toxicity in dogs at doses 0.1 g/kg.
True or False: The BEST assessment of the case: “The dose ingested is below toxic threshold."
False (dose = 0.42 g/kg > 0.1 g/kg)
A pediatrician contacts a pharmacist to request an adjustment in the concentration of an antibiotic suspension. The goal is for the child to receive 180 mg of amoxicillin per teaspoon. The amoxicillin powder label indicates that adding 69 mL of purified water produces a final volume of 100 mL with a concentration of 200 mg per 5 mL. How many milliliters of water must the pharmacist add to the powder to obtain a concentration of 180 mg per teaspoon?
80 mL