Aerie

Package Insert

100

Rhopressa indication

Rhopressa .02% is a Rho kinase inhibitor indicated for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension

200

Name the contraindications of Rhopressa

NONE

300

How supplied, amount in bottle and size

2.5ml fill in a 4 ml container

400

What do you do if you miss a dose

Advise patients that if one dose is missed, treatment should continue with the next dose in the evening

500

Name which adverse event has 53% and which 3 have approximately 20%

53%- conjunctival hyperemia

20%- corneal verticilata, instillation site pain, conjunctival hemorrhage

Competition

100

Which drug class is contraindicated for use in patients with overt cardiac failure

Beta Blockers

200

IOP lowering for PGA's

25-35%

300

IOP Lowering for Alpha agonist

18-25%

400

Latanoprost works to lower intraocular pressure via which mechanism

Increasing uveoscleral outlfow

500

Dosing

PGA

CAI

Beta Blockers

Alpha Agonists

PGA-1

CAI- up to 4 times

Beta Blockers- 2

Alpha Agonists- 3

Competition Continued

100

Blepharitis is an adverse reaction associated with which products

Simrinza, Azopt, Alphagan P

200

Eye Pruritis is typical adverse effect for

Alphagan, Combigan

300

Name all of the PGA's (5 in total)

Xalatan, Lumigan, Travatan Z, Ziopan, Vyzulta

400

What are the market advantages of Rhopressa

First Rho kinase inhibitor in the US, no contraindications

500

What products are competition with Rhopressa

All topical treatments that reduce IOP in OAH/OHT except for PGA's

Rhopressa Studies

100

In the Rocket 2 study, which treatment provided the largest numeric reduction in IOP (up to 5.4 mmHG)

Rhopressa .02% BID

200

In the phase 3 studies (Rocket 1, Rocket 2, and Rocket 4) what was the most prevalent ocular AE observed

Conjunctival hyperemia

300

How long was 

Rocket 1

Rocket 2

Rocket 3

Studies

Rocket 1- 3 months

Rocket 2- 12 months

Rocket 3- 6 months

400

How many total patients were studied in Rocket 1, Rocket 2 and Rocket 4

Rocket 1- 411

Rocket 2- 756

Rocket 3- 708

Total-1875

500

In the Rocket 1 study, Rhopressa administration was associated with statistically significantly larger reductions in mean IOP in patients who were on a ________ prior to study entry compared with those who were not

PGA

Rhopressa

100

Rhopressa  is available in what dosage form and strength

Opthalmic solution containing .2 mg/ml of netarsudil

200

Complete the sentence: As a rock inhibitor Rhopressa works at the cellular level in the TM to block the formation of stress fibers and 

increased trabecular outflow

300

Rhopressa is thought to lower intraocular pressure primarily through its inhibition of 

Rho kinase

400

Explain the efficacy of Rhopressa

Three clinical studies demonstrated up to 5 mmHG reductions in IOP in patients treated with Rhopressa .02% once daily in the evening

500

Accurately describe corneal verticillata

It typically resolves after the medication causing it is discontinued.  It is rarely associated with reduction in visual acuity