AI Guided Drug Repurposing for Alzheimer’s Disease

The Disease

100

This is the projected number of people living with Alzheimer's by the year 2050.

What is 139 Million

200

Alzheimer's is described as this type of complex, multifactorial disorder

Neurodegenerative

300

At the cellular level, this process occurs inside the cell when tau tangles form.

Hyperphosphorylation

400

During this clinical stage, the patient appears healthy but plaques are already forming.

Preclinical

500

This term refers to the shrinkage and decrease in size of the brain during the Dementia stage

Atrophy

Biological Pathways

100

These enzymes, specifically β and 𝛾, are responsible for cutting proteins into toxic fragments.

Secretases

200

These toxic fragments, Aβ40-42, eventually clump together to form these outside of neurons.

Plaques

300

Triggered by Aβ40-42, GSK3 and CDK5 create these, leading to cell death

Tau Tangles

400

This is the term for "programmed cell death" that results from the signaling pathway failure

Apoptosis

500

This is the estimated annual worldwide cost of "Informal Care" for Alzheimer's patients

$520 Billion

AI and Tech

100

This type of AI model is a "visual tool" used for spotting physical brain atrophy in images

CNNs

200

This type of model views the brain as a web of "nodes and edges" to map biological pathways

GNNs

300

 AI can predict if a drug can pass through this protective wall, which blocks 98% of drugs

Blood-Brain Barrier (BBB)

400

This specific AI model targets mitochondrial health and glucose metabolism to power up dying neurons

DeepDrug

500

These two specific drugs are mentioned as a synergistic combination to reduce inflammation

Empagliflozin and Baricitinib.

Treatment and Detection

100

These traditional medical tests for Alzheimer's are often considered too expensive for early detection.

PET scans or lumbar punctures

200

New tools from this University can predict the progression of Alzheimer's with 80% accuracy.

University of Cambridge

300

This is the current estimated cost to develop a single drug for clinical trials.

$2.6 Billion

400

AI categorizes patients into these three progression groups: Stable, Slowly Progressive, or this

Rapidly Progressive

500

This is the failure rate percentage for drugs currently in clinical trials.

90%