Clive’s hives
term for pressure-induced urticaria
Dermographism/dermatographism
Patient develops urticaria, shortness of breath and wheezing, vomiting and diarrhea after one dose of amoxicillin. However, the patient refuses IM epi. What other ROA is available which achieves similar serum concentrations to IM epi?
Intranasal
Eponym for accentuated lines or folds below the lower lids associated with allergic conjunctivitis
Dennie-Morgan lines
These two diagnostic tests can be used to support a diagnosis of IgE-mediated food allergy in patients with consistent clinical histories.
Skin testing and serum IgE testing
Patient presents with delayed umbilical cord separation
Leukocyte adhesion deficiency
This is the mainstay of treatment for urticaria
H1 antihistamines
Name two contra-indications for oral amoxicillin challenge
Anaphylaxis, SCARs, positive skin test
This is how metals allergies are tested
Patch testing
This diagnosis occurs when eating raw fruits, vegetables, or nuts causes itchy lips, mouth, or throat without other systemic symptoms
Oral allergy syndrome
patient presents with Neisseria bacteremia (not meningitidis or gonorrhea) secondary to this innate immune system deficiency
C5-C9 complement defects/deficiencies
This autoimmune condition is associated with chronic urticaria
Hashimoto’s (autoimmune hypothyroidism)
Patient develops joint pains, fever, and rash 8 days into amoxicillin course; this is the type of hypersensitivity reaction, and it is mediated by these components
type III, immune complexes or antibody/antigen complexes
Poison ivy is mediated by this type of cell, causing it to be classified as this type of hypersensitivity reaction
T-cell mediated, type IV
Delayed, non-IgE mediated food allergy primarily affecting the gastrointestinal (GI) tract, causing severe vomiting, diarrhea, lethargy, and dehydration hours after consuming trigger
FPIES
Two month old with eczema, diarrhea, and failure to thrive is admitted for sepsis due to this underlying pathology
SCID
Condition associated with urticaria pimentosa
Mastocytosis (systemic or cutaneous)
Doug is started on carbamazepine and develops fever, malaise, and coalescing targetoid type erythematous macules and mucocutaneous lesions due to this disease.
SJS/TEN
name four treatments approved for eczema
Emollients, topical steroids, calcineurin inhibitors (tacrolimus, pimecrolimus), JAK inhibitors, dupixent (anti-IL 4 and IL 13 mab), and PDE4 inhibitors (crisaborole)
Misdiagnosed as food allergy, this occurs after eating seafood and developing nausea and vomiting
Scombroid poisoning
Patient presents with liver abscess, and further history reveals they have history of numerous staph skin infections and aspergillosis infection secondary to this underlying disease
Chorionic granulomarous disease
This monoclonal antibody is FDA approved for chronic spontaneous urticaria in patients who remain symptomatic despite H1 antihistamine treatment
Xolair (omalizumab)
Patient develops numerous non-follicular pustules and fever within hours after being administered piperacillin, starting in arm pits and spreading outward
Acute generalized exanthemous pustulosis (AGEP)
Severe cutaneous reactions (SCARs) include AGEP, DRESS, SJS/TEN
C1-inhibitor deficiency, either hereditary or acquired, causes angioedema through increased plasma concentration of this vasoactive peptide.
Bradykinin
This syndrome can be induced after lone-star tick bites, leading to delayed IgE mediated anaphylactic-type reactions after consuming mammalian meat
Alpha-gal syndrome
DAILY DOUBLE: this diagnosis occurs when patients eat specific foods and exercise in close proximity to eating that food, leading to anaphylaxis-type symptoms
Food dependent exercise induced anaphylaxis