Soliris PI
What is the indication for soliris that competes w Uplizna: Be specific
The treatment of neuromyelitis optica spectrum disorder (NMOSD) in adult patients who are anti-aquaporin-4 (AQP4) antibody positive
How many patients were in this study
143
96 in the Soliris group and 47 in the placebo
This agent used MRI as an adjudication criteria
Uplizna
True or false 35% of all NMO cases present w Transverse Myelitis
False 50% do and 35% are optic neuritis
Number one grossing movie of 2023
Barbie 1.44 billion world wide
what is the initial dosing schedule
5 doses 1 week apart
Doses 1-4: 900 mg IV qWeek for first 4 weeks, followed by
Dose 5: 1200 mg IV 1 week later, THEN
1200 mg IV q2Weeks thereafter
True or false the relapse reduction rate in this pivotal trial was 78%
False
that was sakurastar (Enspryng)
This agent enrolled patients in it's trial with an EDSS Score of < or equal to 8.0
Uplizna
This percentage of patients w NMO had partial or no recovery after a optic neuritis
67%
During World War 2 what were Oscars made out of?
Wood Metal was scarce.
Name at least one other indication for Soliris other than NMO
The treatment of patients with paroxysmal nocturnal hemoglobinuria (PNH) to reduce hemolysis.
The treatment of patients with atypical hemolytic uremic syndrome (aHUS) to inhibit complement-mediated thrombotic microangiopathy.
The treatment of generalized myasthenia gravis (gMG) in adult patients who are anti-acetylcholine receptor (AchR) antibody positive.
what percentage of patients were on more than one drug in this trial
74%
Which agent has a 2x dosing regiment
Both
Uplizna 2x/yr
Soliris dosed every 2 weeks
true or fales:
AQP4 is a water channel protein expressed in astrocytes in the PNS, predominately in the brain, spinal cord and optic nerve.
false it's in the CNS not PNS
Gilligan actually had another name for his character it was?
A) Dobie B) Willie C) Billy D) Johnny E) Jonas
B: Willie
name 2 of the most commonly reported side effects of Soliris
headache, nasopharyngitis, back pain, and nausea
what percentage of attacks were rejected through adjudication
11/14 or 79%
Which agent reports a 96% reduction in relapse rate
Soliris
True of false in 2021 at ECTRIMS an international panel of NMOSD experts developed and validated through a Delphi consensus and agreed
monotherapy is preferred, patients should be aware of therapy dosing frequency, route of administration, potential safety risks, and that after severe attacks patients preference to other therapies should be considered
False:
This was in 2022 the rest is true
This cult favorite starred Bruce Willis, Andie MacDowell and Danny Aiello
Hudson Hawk
Describe and explain as much a you can regarding the Soliris black box warning
Life-threatening and fatal meningococcal infections have occurred in patients treated with Soliris and may become rapidly life-threatening or fatal if not recognized and treated early (5.1). • Comply with the most current Advisory Committee on Immunization Practices (ACIP) recommendations for meningococcal vaccination in patients with complement deficiencies (5.1). • Immunize patients with meningococcal vaccines at least 2 weeks prior to administering the first dose of Soliris, unless the risks of delaying Soliris therapy outweigh the risks of developing a meningococcal infection. (See Warnings and Precautions (5.1) for additional guidance on the management of the risk of meningococcal infection.) • Vaccination reduces, but does not eliminate, the risk of meningococcal infections. Monitor patients for early signs of meningococcal infections, and evaluate immediately if infection is suspected. Soliris is available only through a restricted program under a Risk Evaluation and Mitigation Strategy (REMS). Under the Soliris REMS, prescribers must enroll in the program (
Name at lest 2 of the 4 Soliris Adjudication criteria
1. Prior stability for > or equal to 30 days
2. New onset/worsening neurological sympton tat persists for >24hrs
3. confirmation on neurological exam
4not attributable to other causes
In cases of concomitant Plasmapheresis, Plasma Exchange, which agent requires supplemental dosing within 60 minutes after each plasma exchange or plasmapheresis
Soliris
Patients w NMO are 4X more likely to have an autoimmune comorbidity name at least one of the most common comorbidities
Lupus erythematosus
Rheumatoid Arthritis
Sjogren's Syndrome
Which CHARACTER (non-starring role) actor's including cameo's has grossed more money than any other in history?
The highest grossing character actor ever is Marvel Comics guru Stan Lee, whose brief appearances in every single Marvel movie until his death amount to a total gross of about $30 billion.