UTI
The PO beta-lactam with the highest bioavailability
What is cephalexin?
The bacteria associated with most SSTIs
What are staphylococcus and streptococcus?
The dose of PO cefdinir for outpatient CAP treatment
What is 300mg BID?
The antibiotic that has excellent lung penetration but is inactivated by surfactant in the lungs
What is daptomycin
The gene that differentiates MRSA from MSSA and is detected in the MRSA NAAT test
What is mecA (and mecC)?
The urinalysis marker that is the most sensitive (but not specific) for diagnosing a UTI
What is pyuria/WBC?
The shortest duration of treatment recommended for uncomplicated SSTI
What is 5 days?
The atypical bacteria associated with pneumonia
What are mycoplasma, chlamydia, legionella?
The reason we dose meropenem as 500mg Q6 rather than 2g Q8 for most infections
What is increased T>MIC and lower daily doses?
The margin of error of calculated breakpoints
What is one dilution?
The only patients that require treatment for asymptomatic bacteruria
Who are pregnant patients, kidney transplant patients, and those undergoing a urologic procedure? (+/- pediatrics)
Three locations of SSTI infections where you might find gram negative involvement
What are groin, axilla, and feet?
The minimum treatment durations for CAP and HAP
What are 5 and 7 days?
The pharmacodynamic parameter of fluoroquinolones
What is AUC/MIC or Cmax/MIC?
Name 3 classes of antibiotics that can be used to treat ESBL infections (if susceptible)
What are carbapenems, fluoroquinolones, sulfonamides, aminogylcosides, and tetracyclines?
(also macrobid, fosfomycin for UTIs)
Two non-beta-lactam antibiotics that can be used to treat cystitis for only 3 days
What are ciprofloxacin and TMP/SMX?
The reason patients with cellulitis often have delayed improvement or "look worse before they get better"
What is streptococcus toxin release?
The most common infectious cause of community-acquired pneumonia
What are viruses?
The pharmacodynamic goal for vancomycin
What is AUC/MIC >400?
The resistance mechanism of some "SPACE" organisms that confers resistance to most beta-lactams
What is ampC?
The percent of healthy individuals that will achieve clinical cure for cystitis without antibiotics
What is 25-42%?
The bacteria most often associated with necrotizing fascitis (name 2)
What are S.pyogenes, S.aureus, V.vulnificus, A.hydrophila?
The prevalence of MRSA CAP within Providence OR Region
<1%
The only beta-lactam with a serum/lung ratio of 100%
What is cefepime?
The trial in which piperacillin/tazobactam displayed inferiority to meropenem for ESBL blood stream infections
What is the MERINO trial?