Anemia and Transfusion Jeopardy

Nutritional Anemia

100

The area of the intestines where iron is absorbed

Duodenum

200

Overconsumption of milk leads to iron deficiency by what mechanism (s)

Microvillus sloughing and depression of iron absorption

300

The order of lab values to correct in iron deficiency anemia being treated with supplemental iron

Hemoglobin

RBC indicies (MVC MCHC)

Transferring & TIBC

Ferritin

400

Drinking unpasturized goat's milk will lead to this deficiency

Folate

500

Vitamin B12 deficiency will lead to defective DNA synthesis causing megaloblastic anemia and what other side effects?

Jaundice

glossitis

Neurological deficits

Reticulocytopenia

Hypersegmented neutrophils

Hemolytic Anemia

100

This is the most common cause of non-immune hemolytic anemia

Hereditary Spherocytosis

200

Helmet cells, bite cells, Heinz bodies and spherocytes are all signs of this hemolytic anemia

G6PD deficiency

300

Alloimmunization but not hemolysis does occur in the first pregnancy with this most immunogenic blood antigen

Rh

400

IgG mediated, Extravascular coombs positive hemolytic anemia

Warm Reactive Autoimmune Hemolytic Anemia

500

Seen in vasculitis, DIC, TTP, HUS, congenital heart disease

Schistocytes

Thalassemia

100

Tetramers of gamma globins

Hemoglobin Barts

200

--/alpha -

Hemoglobin H disease/Alpha Thalassemia intermedia

300

Mom B/B0

Dad B/B+

Odds child will have beta thalassemia intermedia

Odds child will have beta thalassemia trait 

25%

50%

400

--/-- leads to severe transfusion dependent anemia requiring in-utero transfusions and HSCT for survival

Hydrop fetalis

500

This leads to free radicals and ROS species that damage organs leading to heart, liver and pituitary failure in patients with hemoglobinopathies

Iron overload or hemochromotosis

Genetics

100

Hereditary spherocytosis is typically a ____ mutation in spectrin or ankrin, less commonly protein 4.2 or band 3

Autosomal Dominant

200

Hereditary pyropoikilocytosis is a ______ mutation in spectrin leading to severe anemia in childhood that improves in adulthood

Atosomal recessive

300

A 4 yo boy has a spider bite that gets infected and is placed on bactrim. 2 days later he is brought to the ER for severe abdominal pain, yellow color, fatigue and headache. How is this disorder inherited? 

X-linked recessive

400

Mom has alpha thalassemia trait cis mutation

Dad normal

odds children will have alpha thalassemia minor

50%

500

Mom alpha thalassemia minor trans mutation

Dad normal

Odds children will have alpha thalassemia trait vs normal vs silent carrier

100% silent carrier

Transfusion Medicine

100

Platelets are stored at this temperature

Room temperature or 24*C

200

This is the only way to prevent TA-GVHD

Irradiation

300

this evaluates compatibility between the donor blood and the recipient

Crossmatch

400

Name 2 plasma indications

 DIC

Liver failure

Warfarin reversal

factor deficiency and no factor available

Plasma exchange

500

4 hours after blood transfusion patient presents with fever, shortness of breath, pulmonary edema, hypotension

TRALI