How IRONic
Having a BLAST!
You're not my type
Type A peronality
It isn't in my blood
100
these are the RDW and RPI levels in iron deficiency anemia
high RDW, low RPI (can't make reticulocytes)
100
this anemia can be associated with spinal demyelination in its most severe form
What is B12 deficiency anemia?
100
these are the microcytic anemias
What are
1. thalassemia
2. anemia of chronic disease
3. Iron deficiency anemia (late)
4. lead poisoning. ?
100
These are the normocytic non-hemolytic anemias
What are
1.Aplastic anemia
2. CKD
3. Iron deficiency (early)
4. anemia of chronic disease (early)
100
these are the extrinsic hemolytic anemias
What are
1. hereditary spherocytosis
2. G6PD deficiency
3. PK deficiency
4. PNH
5. SCD
6. HbC disease
200
these are the most common causes of ID anemia
GI bleeding, menstural bleeding, pregnancy, gastric surgeries, celiac disease
200
Dx: bone marrow biopsy shows hypocellularity
What is aplastic anemia?
BONUS: What is the most common lab finding seen with aplastic anemia?
200
loss of biconcave disc => loss of ability to deform through splenic cord sinusoids => early clearance from circulation
What is hereditary spherocytosis?
200
severe macrocytic anemia mostly seen in pts < 1 y/o
What is Diamond-Blackfan anemia?
200
These are the intrinsic hemolytic anemias
What are
1. autoimmune
2. MAHA
3. MIHA
4. infection ?
300
this is how you differentiate between ID anemia and anemia of chronic disease
What are ferritin and transferrin levels?
ID anemia: low ferritin, high tranferrin
**opposite in ACD
300
increased homocysteine, normal MMA, no neurologic sx
What is folate deficiency?
300
macrocytic anemia + pancytopenia
What is Fanconi anemia?
BONUS: What is the inheritance pattern?
300
these are the non-megaloblastic macrocytic aanemias
What are
1. Diamond-Blackfan anemia
2. liver disease
3. chronic alcohol overuse ?
300
DAT shows: IgG-, C3+
What is cold agglutinin disease?
400
these are common clinical presentations of iron deficiency anemia
What are fatigue and decreased cognitive function?
400
these are the megaloblatic macrocytic anemias
What are
1. folate deficiency
2. B12 deficiency
3. Orotic aciduria
4. Fanconi anemia. ?
400
CD55/59 absence of RBCs by flow cytometry
What is PNH?
400
these three antimicrobials are known to exacerbate disease in someone with G6PD deficiency
What are dapsone, nitrofuratonin, and quinolones?
BONUS: What are the 3 other drugs?
400
B12 deficiency due to autoantibodies against IF and/or gastric parietal cells
What is pernicious anemia?
500
best measure of iron stores in the body
What is ferritin?
500
X-linked recessive, glutathione deficiency
What is G6PD deficiency?
500
clinical presentation: degree of anemia may not correlate with sx
diagnosis: smear = Burr cells (echinocytes)
What is PK deficiency?
500
pathophysiology: disruption in production of heme for hemoglobin
What is sideroblastic anemia?
BONUS: What is the most common mutation in hereditary sideroblastic anemia?
500
this peripheral blood smear is indicative of what kind of anemia?
B12 deficiency induced anemia