It's Getting Hot in Here
A drug NOT metabolized by plasma cholinesterase.
A.Remifentanil
B.Heroin
C.Cocaine
D.Mivacurium
What is…
A. Remifentanil?
This drug may cause increased QT interval in poor metabolizers of CYP2D6.
What is Methadone?
A behavioral syndrome characterized by evidence of psychological dependence (craving), drug use despite harmful side effects, and other drug-related aberrant behavior.
What is Addiction?
Avoid in pregnant patients:
A. Naloxone
B. Methadone
C. Buprenorphine
D. Naltrexone
What is...
A. Naloxone
Name a rule of owning a Mogwai (to prevent it from turning into a Gremlin). Hint: 3 rules
The name of this category befitting a patient with a heterozygous plasma cholinesterase enzyme.
What is 30-60?
Fluoxetine may lessen its analgesic effect.
A. Acetaminophen
B. Oxycodone
C. Fentanyl
D. Bupivacaine
What is...
B. Oxycodone
This is NOT a common risk factor for patient misuse of prescribe opioids.
A. Smoker
B. Lower post-op pain
C. Family member with substance abuse disorder
D. Psych history
What is...
B. Lower post-op pain
This drug has the highest affinity for mu receptor
A. Methadone
B. Fentanyl
C. Naloxone
D. Buprenorphine
What is...
D. Buprenorphine?
Michael Myers' mask is of this person.
Who is Captain Kirk?
Dantrolene:
A. antagonizes the effect of non-depolarizing muscle relaxants
B. produces clinically detectable muscle weakness when administered intravenously prior to anesthesia
C. is indicated for neuroleptic malignant syndrome
D. May cause hepatic failure when used prophylactically before anesthesia
D.has increased effectiveness when combined with calcium entry blockers
What is...
B. Produces clinically detectable muscle weakness when administered intravenously prior to anesthesia
The most likely cause of further reduction of butyrylcholinesterase activity of a person with a heterozygous enzyme.
A. Hyperlipidemia
B. Alcoholic cirrhosis
C. Obesity
D. Echothiopate
What is...
D. Echothiopate?
The type of substance use disorder in which users suffer from withdrawal.
A. Addiction
B. Tolerance
C. Dependence
D. Intoxication
What is
C. Dependence?
Medication most likely to ease withdrawal symptoms.
A. Methadone
B. Clonidine
C. Naloxone
D. Naltrexone
What is..
B. Clonidine?
This is the slasher with the HIGHEST kill count. (Total across all franchises)
Who is Jason Voorhees?
•His actual body count is a little controversial, ranging from 146-157 murders.
15-kg, 3-year-old for inguinal hernia repair gets sux 30 mg at induction. After 45 mins, kid is not breathing; peripheral nerve twitch monitor indicates no train-of-four. This is the most likely explanation.
A. abnormal response to non-depolarizing muscle relaxants
B. low dibucaine number
C. low plasma cholinesterase concentration
D. underlying myopathy
E. positive caffeine-halothane contracture test
What is...
A. low dibucaine number?
A common mechanism of drug-induced QT-prolongation is alteration of a channel involving this electrolyte.
What is Potassium?
This is the most common early indication of drug dependence in an anesthesiologist.
A. positive random drug screen
B. inconsistency between anesthetic and drug control records
C. change in behavior
D. incapacitation due to overdose
E. the presence of needle tracks on the extremities
What is...
C. a change in behavior?
Only opioid with NMDA antagonist effects.
A. Fentanyl
B. Hydromorphone
C. Methadone
D. Buprenorphine
What is...
C. Methadone?
Freddy Krueger killed this future A-list actor with a bed in A Nightmare on Elm Street (1984).
Who is Johnny Depp?
64-year-old, 70-kg woman on lithium is given methohexital 90 mg, sux 35 mg iv for ECT. 10 min later, remains sedated; peripheral nerve stimulator shows decreased twitch response. This is the most likely explanation.
A. cerebral hypoxia
B. post-ictal depression
C. overdose of methohexital
D. unrecognized atypical pseudocholinesterase
E. residual lithium effects
What is...
E. residual lithium effects?
How CYP2D6 genetic polymorphisms may affect codeine analgesia.
(hint: looking for 2 things)
•Ultra rapid metabolizers- convert too much codeine into morphine, may OD
•Poor/Slow metabolizers- inadequate pain relief due to insufficient conversion of codeine to morphine
After termination of an inhalation anesthetic, patient-controlled analgesia will…
A. be effective without a loading dose of opioid if started in the immediate post-anesthetic period
B. be associated with greater analgesic requirements than conventional intramuscular opioid techniques
C. cause addiction or dependence to opioids if continued for more than 72 hours
D. produce less patient satisfaction than intermittent intravenous administration of opioids
E. show a diurnal variation in analgesic requirement
What is...
E. show a diurnal variation in analgesic requirement?
Can treat alcoholism
A. Butorphanol
B. Naltrexone
C. Nalbuphine
D. Methadone
What is...
B. Naltrexone
This was the budget of The Blair Witch Project. (closest estimate, over or under, wins)
What is $60,000?
•It made $250 million worldwide, making it one of the most successful indie films.
•Paranormal Activity had a budget of ~$11,000.