NRTI
Was the first available NRTI and antiretroviral
What is zidovudine (AZT)?
This phamacokinetic enhancer (or "booster") was used as active antiretroviral in the past.
What is ritonavir (RTV)?
This agent was the first commercially available INSTI.
What is raltegravir?
This agent has been associated with fulminant liver failure accompanied by generalized rash.
What is nevirapine (NVP)?
This is the only INSTI recommended during pregnancy by DHHS Perinatal Guidelines.
What is raltegravir?
This agent was first associated with increased risk of cardiovascular events in the Danish cohort D:A:D in 2010.
What is abacavir (ABC)?
These three metabolic abnormalities, the hallmark of metabolic syndrome, are associated with all protease inhibitors.
What are dyslipidemia, glucose metabolism abnormalities, and fat redistribution?
This agent has preliminarily been associated with teratogenicity, and should be avoided during pregnancy.
What is dolutegravir (DTG)?
This agent is associated with all kinds of psychiatric and CNS toxicities.
What is efavirenz (EFV)?
This third agent class is now recommended for most people with HIV-1.
What are the INSTI?
These two agents are chemically identical except for their differing atoms (F or H) at the third position.
What are emtricitabine (FTC) and lamivudine (3TC)?
This cardiac conduction abnormality is associated with most protease inhibitors.
What is prolongation of P–R interval?
This agent is the only INSTI that requires a pharmacoenhancing ("boosting") agent.
What is elvitegravir (EVG)?
This is the only antiretroviral associated with a false positive cannabinoid test.
What is efavirenz (EFV)?
This product is the only agent that is FDA-approved for HIV PrEP.
This agent is a closely related to adefovir (Hepsera®) but has higher potency against HIV.
What is tenofovir (TFV)?
This product is the only single-tablet regimen containing a boosted protease inhibitor in the market.
What is Symtuza®?
Divalent cations.
What are agents that chelate INSTIs and prevent their intestinal absorption?
This agent is known to induce its own hepatic metabolism, requiring an increase in dose after the second week of initiation.
What is nevirapine (NVP)?
This agent was approved in March, 1987.
What is zidovudine?
This is the most common NRTI mutation, which also decreases viral replication capacity.
What is the M184V?
This agent was discovered and developed by a chemist in the East campus at UIC, and generates one of the highest royalties for the university.
What is a big, fat lie?
This is one of the most common NNRTI genetic mutations in the reverse transcriptase enzyme.
What is the K103N?
150 mg of cobicistat is bioequivalent to 100 mg or ritonavir for boosting darunavir and atazanavir, but not this older agent.
What is tipranavir (TVP)?