Anti-hyperlipidemia Meds

1

100

What is your favorite statin?

Atorvastatin :)

200

What is the most common side effect of statins?

Myopathy

300

What is the MOA of statins?

Inhibits HMG-CoA reductase

400

In a lipid panel what values will likely be decreased when a patient is on a statin?

Big dec. in LDL & lesser dec. in Triglycerides

500

What other adverse effect can be caused by statins?

Hepatotoxicity- so look at LFTs

2

100

What is the brand name for Ezetimibe?

Zetia

200

What is the MOA of Ezetimibe?

Dec. intestinal cholesterol absorption

300

In a lipid panel what lab value will likely be decreased with Ezetimibe?

Dec. in LDL

400

If Ezetimibe is given concurrently with a statin what is the possible adverse effect?

Hepatotoxicity 

500

Name as many Bile acid sequestrants as you can?

Cholestyramine, Colestipol, Colesevelam

3

100

What is the MOA of Bile acid sequestrants?

prevent reabsorption of bile acids in the intestine

200

What lab value do you expect to decrease on a lipid panel in a patient on bile acid sequestrants?

Dec. in LDL

300

What are the possible adverse effects of bile acid sequestrants?

Nausea, bloating, and cramping, impaired drug and fat soluble vitamin absorption

400

What is the MOA of Niacin?

dec. in FA release, VLDL synthesis, and HDL synthesis

500

What lab value is decreased and what lab value is increased with the use of Niacin?

Dec. in LDL and high increase in HDL

4

100

What are some adverse effects of Niacin?

Flushing, pruritus, hepatotoxicity, hyperuricemia

200

Name as many fibrates as you can?

Gemfibrozil & fenofibrate

300

What is the MOA of fibrates?

Activate PPAR-a and dec. VLDL synthesis

400

What lab value can be decreased and what lab value can be increased with fibrates?

dec. in Triglycerides and inc. in HDL

500

If fibrates were to be used in conjunction with statins what adverse effect can we expect?

Muscle Toxicity

5

100

Can you name one more adverse effect of fibrates?

Gallstones

200

What is the MOA of Omega-3 fatty acids?

dec. in VLDL synthesis and Apo B synthesis

300

What lab value is decreased with the use of Omega-3 fatty acids?

Dec. in triglycerides

400

What lab value is increased with the use of Omega-3 fatty acids?

Inc. in HDL

500

What is the adverse effect of Omega-3 fatty acids?

Fishy taste lol