Show:
PK/PD For You and Me
Get Some Action
Oops, I did it again
Wanna go to CYPs?
Snug as a Bug
100
The pharmacodynamic predictor of efficacy for beta-lactam antibiotics.
What is time > MIC?
100
The mechanism of action for amoxicillin.
What is inhibition of cell wall synthesis?
100
This antibiotic carries a black box warning for fatal colitis.
What is clindamycin?
100
The two classes of antibiotics that must be separated from milk.
What are tetracyclines and fluoroquinolones?
100
The fluoroquinolones that are active against s.pneumoniae.
What are levofloxacin and moxifloxacin?
200
The time period of continued bacterial growth suppression after the concentration of an antibiotic decreases below the MIC.
What is the post-antibiotic effect (PAE)?
200
The mechanism of action for fluoroquinolones.
What is inhibition of DNA topoisomerase IV and DNA gyrase.
200
While this class of antibiotics has been associated with nephrotoxicity and ototoxicity, it carries a black box warning for neurotoxicity.
What are aminoglycosides?
200
Administration of this antibiotic with warfarin is likely to cause the INR to decrease.
What is rifampin?
200
The only antibiotic with solely anaerobic coverage.
What is metronidazole?
300
In order to be considered to exhibit "bactericidal" activity, an antibiotic must meet this criteria.
What is a 3log kill in 24 hours?
300
The mechanism of action for erythromycin.
What is inhibition of protein synthesis by binding to 50S ribosomal subunit?
300
This antibiotic is associated with skin reactions, hyperkalemia, and photosensitivity.
What is TMP/SMX?
300
Foods and drinks such as certain cheeses, sauerkrat, and beer should be avoided when taking this antibiotic.
What is linezolid?
300
This cephalosporin is active against Enterococcus.
What is NONE OF THEM?!
400
For optimal efficacy of penicillins and cephalosporins, the serum drug concentration must be above the MIC for what percentage of the drug interval?
What is 60-70%?
400
The mechanism of action for daptomycin.
What is cell membrane depolarization?
400
This antibiotic should only be administered through a central line due to a high risk of phlebitis.
What is quinupristin/dalfopristin?
400
This macrolide has the least effect on the CYP450 system.
What is azithromycin?
400
The only cephalosporin that is active against MRSA.
What is ceftaroline?
500
For optimal efficacy of carbapenems, the serum drug concentration must be above the MIC for what percentage of the drug interval?
What is 40-50%?
500
The mechanism of action for sulfamethoxazole and trimethoprim.
What is inhibition of folate synthesis?
500
The only class of penicillins that are eliminated by the liver.
What are antistaphylococcal penicillins?
500
Administration of this antibiotic with neuromuscular blocking agents is not recommended.
What are aminoglycosides?
500
The carbapenems that are active against Pseudomonas.
What are doripenem, meropenem, and imipenem?