Antibodies and Hypersensitivity

Hypersensitivity 1

2

Hypersensitivity reactions types I, II, and III are collectively known as _______________.

Immediate Hypersensitivity

4

Antibodies that are blocked in chronic desensitization

IgA and IgG

6

What are the mediators of Immediate and Delayed Hypersensitivity?

Immediate - Antibodies

Delayed - T cells

8

The tuberculin skin test is carried out to determine whether an individual has been previously exposed to what organism?

MYCOBACTERIUM TUBERCULOSIS

10

A harmful immune response in which tissue damage is induced by exaggerated or inappropriate immune responses in a sensitized individual on re-exposure to the same antigen.

Hypersensitivity

Antibodies 1

2

The Ig with the longest half-life and highest serum concentration.

Immunoglobulin G

4

Antibodies derived from a single clone of plasma cell.

Monoclonal antibody

6

Second most abundant Ig class that is found in bodily secretions

Immunoglobulin A

8

mAb used in the treatment and management of Rheumatoid arthritis

Adalimumab / Infliximab

10

The Ig that can cross the placenta thus providing immunity to the fetus.

Immunoglobulin G

MekusMekus

2

An acute, potentially fatal, and systemic manifestation of immediate hypersensitivity reaction.

Anaphylaxis

4

Enumerate the four common manifestations of Atopy

Asthma, Rhinitis, Urticaria, and Atopic dermatitis

6

Mechanism of action of Bevacizumab and Abciximab

Inhibit angiogenesis

8

IgE is elevated in _____________ infections

Helminthic

10

Serum sickness is a manifestation of what Type of Hypersensitivity reaction?

Type III

Antibodies 2

2

Ig that is only present in the intravascular compartment, not in body fluids or secretions.

Immunoglobulin M

4

It is prepared by recombination of 34% mouse proteins and 66% human proteins.

Chimeric Monoclonal Antibody

6

Antibody involved in Type I Hypersensitivity

Immunoglobulin E

8

Produced by patients suffering from Multiple myeloma

Bence Jones Proteins

10

Antibody found as membrane Ig on the surface of B cells and acts as a B cell receptor along with IgM.

Immunoglobulin D

Hypersensitivity 2

2

Classified hypersensitivity reactions into four categories based on the time elapsed from exposure of antigen to the reaction and the arm of immune system involved.

Gell and Coombs

4

The administration of small amounts of antigen to which the person is sensitive, at an interval of 15 minutes.

Acute desensitization

6

What does ADCC stands for?

Antibody-dependent-cell-mediated cytotoxicity

8

The reaction time of contact hypersensitivity

48-72 hours

10

Delayed Hypersensitivity is ______-mediated.

Cell