Antibody
The most common antibody isotype in the bloodstream.
What is IgG?
These polypeptide chains that make up the TCR.
What are the alpha and beta chains?
Location of antigens loaded for MHC-I
What is endogenous?
Lympocyte-specific enzymes that drive VDJ rearrangement.
What are RAG-1 and RAG-2?
Location of antigens that are presented by MHC-II
What are exogenous antigens?
Isotypes that form dimers and multimers using the J chain.
What are IgA and IgM?
These are recognized by the TCR.
What is an antigen?
Process by which dendritic cells activate naive CD8 T cells by MHC I.
What is cross presentation?
DNA sequences that determine locations of somatic recombination.
What is the recombination signal sequence?
Cells that can present antigen on MHC-II
What are professional antigen presenting cells?
Order of antibody genes on the mouse genome.
IgM/IgD, IgG, IgE, IgA
What is the gamma-delta T cell receptor?
Complex that generates ubiquitinated peptide fragments in the cytosol.
What is the proteasome?
Segments required for BCR heavy chain or TCR beta chain formation.
What are the variable, diversity and joining segments (V, D, and J)?
Binds in the peptide-binding groove of MHC-II until a peptide binds.
What is the CLIP peptide?
Isotype with high affinity with mast cells and basophils.
What is IgE?
These molecules help stabilize interactions between TCR and peptide:MHC class II.
What is CD4?
The process of loading proper antigens in the MHC-I pocket.
These contribute to the diversity of MHC molecules.
What are polymorphism and polygeny?
Enzyme that ubiquitinates MHC-II, targeting it for degradation.
What is MARCH-1 ligase?
Antibody fragment important for binding to immune cells/functionality.
What is the Fc fragment?
These types of antigens are recognized by TCR but not BCR?
What are epitopes buried in the native protein structure?
These proteins form a channel to transport peptides form the cytoplasm into the ER.
What are TAP1 and TAP2 or the TAP transporter?
Name of MHC genes in humans.
What is human leukocyte antigen (HLA)?
What contributes to diversity in MHC peptide binding?