Anticoagulants

Vitamin K Antagonist

100

MOA: blocks vitamin k

Indications of use: Afib, DVT, Pulmonary Embolism 

Side Effects: Bleeding

Monitor Labs

INR should be less than 1 

If taking medication levels should be between 2-5

Vitamin K is the antidote

Warfarin

Xa Inhibitor

100

Inhibits clotting factor Xa 

Given SubQ or IV 

Monitor aPTT or Anti Xa

Antidote: Protime Sulfate

Side Effects: Bleeding 

Heparin

Xa Inhibitor

100

Xa Inhibitor

It differs from Heparin because there is no routine clotting factor. Only give SubQ. Give in the abdomen. Do not expel bubble. Do not massage.

Monitor BUN & CREATININE.

Antidote: Protamine Sulfate.

Enoxaparin/Lovonox

Salicylate

100

Prevents MI, CVA, chronic afib, relieves pain.

SE: GI ulcers, bleeding, nephrotoxic rheyes syndrome. children should not take. stop 5-7 days before surgery.

aspirin

ADP Inhibitor

100

to prevent MI, CVA, or manage cardiac stents

SE: BLEEDING

clopidogrel