name/class
name one common medication in the monoamine oxidase inhibitor class of antidepressants
NO
what is the purpose/indication for Nardil or Parnate?
it helps treat major depressive disorder; it can also be used to treat anxiety disorders or panic disorders
is hypotension a side effect of Nardil and Parnate?
yes
if I am taking adderall for my ADHD, can I also take Nardil/Parnate?
NO
name one other common medication in the monamine oxidase inhibitor class of antidepressants
tranylcypromine (Parnate)
red wine and beer
what is the normal dosage range for Nardil in an adult?
15-90 mg/day
what are some general side effects of an MAOI?
dizziness, insomnia, dry mouth, blurred vision, peripheral edema, weight gain, muscle weakness
what are two risks when taking an MAOI and a decongestant?
hypertensive crisis (headache, nausea and vomiting, chest pain, intercranial bleeding)
distinguish between the generic and trade name of Phenelzine - Nardil
generic: phenelzine
trade: Nardil
how should fish NOT be prepared/eaten?
pickled, aged, fermented, dried, or smoked
what is the normal dosage range for Parnate in an adult?
10-60 mg/day
what can occur if you consume foods high in tyramine while taking an MAOI
you can experience a hypertensive crisis (can be FATAL)
what are two medications that you should not take when taking an MAOI
decongestants (sudafed) or diet/energy medications (vyvanse, didrex)
distinguish between the generic and trade name of Tranylcypromine - Parnate
generic: tranylcypromine
trade: Parnate
give three examples of foods unsafe to consume when taking MAOIs
aged cheese, cured meats, fermented soy products
between Nardil and Parnate, which drug has the longer half-life?
TRICK QUESTION: they both have the same half life; however, Parnate's effects stay in the system longer as they last 3-10 days (Nardil only lasts 3-4)
what are the signs and symptoms of a hypertensive crisis?
severe hypertension, extreme headache, nausea and vomiting, tachycardia, elevated temperature, and changed in level of consciousness
how long should you wait between taking an MAOI and an SSRI (selective serotonin reuptake inhibitor)
14 days (2 weeks)
what medication class are Nardil and Parnate a part of?
MAOI - monoamine oxidase inhibitors
an antidepressant
what compound is found in these foods that makes them unsafe to consume when taking an MAOI
tyramine
what do MAOIs do (what is their action)?
MAOIs block monoamine oxidase receptors in the brain, which increases the reuptake of serotonin and norepinephrine
what are the signs of serotonin syndrome?
confusion, altered mental status, tachycardia, fever, sweating, tremors, seizures, hallucinations, loss of coordination
what other classes of drugs should not be taken with an MAOI