Antiepileptics Fun Facts

Medication Dosing

100

I am dosed 0.1 mg/kg IV push for emergent initial treatment

Lorazepam

200

I am dosed 0.2 mg/kg IV push for emergent initial treatment

Midazolam (can also be given IM)

300

I am dosed 20 mg/kg IVPB for urgent treatment

Fos(phenytoin), phenobarbital

400

I am dosed 40 mg/kg IVPB or IV push for urgent treatment

I am valproic acid

500

I am dosed 60 mg/kg IV push for urgent treatment

Levetiracetam

Mechanisms of Action

100

GABA

BDZ, phenobarbital, pentobarbital, propofol

200

Na blocker

Fos(phenytoin), lacosamide

300

SV2A - Synaptic Vesicle Protein 2A 

Keppra, Briviact

400

GABA, Na blocker, NMDA antagonist

Valproic acid

500

GABA, Na, AMPA antagonist

Topiramate

Adverse Drug Reactions

100

Hepatotoxicity

Valproic acid, phenytoin, felbamate

200

Psychosis

Levetiracetam, parampanel

300

Thrombocytopenia

Carbamazepine, valproic acid

400

Paralytic ileus

Pentobarbital, thiopental

500

Arrhythmias

Lacosamide, fos(phenytoin)

Drug Interactions

100

Fos(phenytoin)

2C19 substrate, inducer; 2C9 substrate, inducer; 3A4 substrate, inducer

200

Valproic acid

2C9 substrate, inhibitor

300

Brivaracetam

2C19 substrate

400

Carbamazepine

2C19 inducer; 2C9 inducer; 3A4 substrate, inducer

500

Clobazam

2C19 substrate; 3A4 substrate, inducer

Continuous Infusions

100

Bolus: 0.2 mg/kg, Infusion: 0.05-2 mg/kg/hr

Midazolam

200

Bolus: 1-2 mg/kg, Infusion: 20-200 mcg/kg/min

Propofol

300

Bolus: 1.5 mg/kg, Infusion: 1-10 mg/kg/hr

Ketamine

400

Bolus: 5-15 mg/kg, Infusion: 0.5-5 mg/kg/hr

Pentobarbital

500

Which continuous infusion should be decreased by 20% every 3 hours?

Propofol, pentobarbital, ketamine