thiazide diuretics
what is the prototype?
HCTZ
What does Renin do?
it catalyzes the formation of angiotensin I from angiotensinogen, this leads to larger amounts of circulation angiotensin II, this is released when BP is lowered
what is the prototype for this?
lisinopril
What is the prototype for this class?
losartan
These CCB's primarily act on blood vessels: they are called dihydropyridines, what is the prototype?
amlodipine
the MOA of this med works in this organ to block the conversion of angiotensin I to angiotensin II, what is this organ?
Lungs
the MOA for this med binds with angiotensin II receptors in vascular smooth muscle and this gland?
adrenal
CCB's that affect vascular and cardiac muscle are called nondihydropyridines, what are the prototypes?
verapamil
diltiazem
in the lungs, this converts angiotensin I to angiotensin II which causes vasoconstriction, what is this?
ACE
this adverse side effect can be persistent, what is this?
dry cough
Which of these patients would not be on this medication:
hypertension patient
patient with kidney disease
pregnant woman
pregnant woman
CCB's will decrease this, cardiac workload and myocardial oxygen demand. what specifically will be decreased?
BP
angiotensin II stimulates the adrenal cortex to release this, what is this?
aldosterone
This medication has a box warning if used during pregnancy, what is this?
risk for major congenital defect
this side effect includes symptoms such as severe swelling of lips, eyes and tongue, occasionally restricting breathing, what is the name for these symptoms
angioedema
what are CV effects that can occur?
hypotension, bradycardia, peripheral edema, and heart block
Aldosterone regulates the volume and pressure and increases this electrolyte and water reabsorption and excretion of K+, what is the volume and pressure and that electrolyte?
blood volume and BP
Sodium
What medication can decrease antihypertensive activity and worsen preexisting renal disease?
NSAIDS
After the angiotensin II is bound in the vascular smooth muscle and the adrenal gland, this is the result
vasodilation and prevents secretion of aldosterone
What is drug/food interactions to be aware of?
other antihypertensives, alcohol (potentiates vasodilation), grapefruit juice (enhances absorption)