Atherosclerosis
What is the name of the disease in which atherosclerosis occurs in the coronary arteries?
Coronary artery disease
What causes angina to occur?
an imbalance between myocardial oxygen demand and oxygen supply
Which antilipemic drug class is never absorbed into the bloodstream?
Bile acid sequestrants
Which vital signs would you expect to change after administering nitroglycerin?
decreased BP, increased HR
How does coronary artery disease lead to angina?
decreased oxygen supply to the myocardium
What is chronic stable angina?
chest pain that only occurs with stress or exertion and is relieved by rest or medications
Which enzyme do statins inhibit?
HMG Co-A Reductase
Which Nitrate is primarily a long-acting form of nitroglycerin?
Isosorbide Mononitrate
What is the role of HDL cholesterol?
Helps remove LDL and VLDL from the body
What are the two ways that angina can be treated?
A patient who started Atorvastatin 2 weeks ago now complains of leg cramps and generalized body aches. What is your primary concern?
rhabdomyolysis
Which two antianginal medications help increase myocardial oxygen supply?
Nitroglycerin, Amlodipine
What lab values would indicate an increased risk of atherosclerosis?
increased LDL/VLDL/TG and decreased HDL
How does a diet high in fats and cholesterol increase a person's risk of angina?
Increased risk of hypercholesterolemia leading to atherosclerosis and poor oxygen supply to heart
Which antilipemic drug class cannot be taken with grapefruit juice?
statins
Nitrates
For a patient that was just diagnosed with hypercholesterolemia, how long should they try to treat it with diet and lifestyle changes before being prescribed medications?
6 months
What is the difference between unstable angina and MI?
MI will show an increased Troponin level and possible EKG changes
Why are fibric acid derivatives and statins not taken with one another?
increased risk of rhabdomyolysis
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