Neuroleptic malignant syndrome
The vital sign change that is most closely associated with neuroleptic malignant syndrome
Fever
Anticholinergics
Precaution or contraindication for FGA: Severe depression
Contraindication
Second-gen
True or false: Extrapyramidal symptoms are more common in first generation antipsychotics than in second generation antipsychotics
True
In neuroleptic malignant syndrome, the extremities that are the most affected by tremor and hyperreflexia
Lower extremities/ legs
The antipsychotic side effect that is enhanced by consuming alcohol
CNS depression
Precaution or contraindication for FGA: Seizure disorders
Precaution
Hormonal condition commonly precipitated by second-generation antipsychotics
Insulin resistance/ type 2 diabetes
Contraindication for FGA or SGA or both: Dementia-related psychosis in the elderly
Both
Abdominal assessment changes that typically accompany neuroleptic malignant syndrome
Hyperactive bowel sounds, sometimes diarrhea
The name of the drug, used for Parkinson's disease, that counteracts antipsychotic drugs by restoring brain dopamine levels
Levodopa
The symptom that means "inability to remain still"
Akathisia
Inflammation of the heart muscle that can be caused by second-generation antipsychotics
Myocarditis
Which antipsychotic class (first or second) is more effective
Both are equally effective
A direct-acting muscle relaxant that is used to treat neuroleptic malignant syndrome
Dantrolene
The arrhythmic effect of antipsychotics that may be enhanced by mood stabilizers containing lithium or by fluoroquinolone antibiotics
Prolonged QT segment/ prolonged QT syndrome
The symptom that means "Involuntary muscle contractions"
Dystonia
Name at least two blood tests commonly used to detect side effects of second-generation antipsychotics (Double Points if you get all four!)
Any combination of metabolic panel, fasting blood sugar, lipid panel, or CBC
Which of the following is a secondary outcome of antipsychotic use? EPS, decrease in LOC, clinical depression, decreased frequency of psychotic episodes (Hint: A secondary outcome is usually used to detect whether a drug has its intended clinical effect)
Decreased frequency of psychotic episodes
A dopamine receptor agonist that is used to treat neuroleptic malignant syndrome
The cellular regulation side effect of second-generation antipsychotics that may be enhanced in a patient undergoing chemotherapy
Common side effect of FGAs that translates as "late erratic movements"
Tardive dyskinesia
How second-gen antipsychotics differ from first-gen antipsychotics at the dopamine receptor site (Hint: This difference leads to fewer EPS side effects)
Loose dopamine receptor binding
Finish the following phrases: Red as a ___, dry as a ___, hot as a ___, mad as a ___ blind as a ___, full as a ___. Double points if you can describe all six mnemonics in terms of symptoms!
Red as a beet (flushing), dry as a bone (dry skin and mucus membranes), hot as a hare (hyperthermia), mad as a hatter (confusion), blind as a bat (mydriasis/ dilated pupils), full as a flask (urinary retention)