This integrase inhibitor should be taken with food.
What is elvitegravir (EVG)?
100
Associated with neural tube defects when given in the first trimester of pregnancy.
What is efavirenz (EFV)?
100
HLA-B*5701 is required prior to initiating this ARV.
What is abacavir?
100
Two regimens no longer included in the recommendations for initial treatment and moved to the alternative regimens category.
What are Atripla (EFV/TDF/FTC) and Reyataz + Norvir (ATV/r) + Truvada (TDF/FTC)?
100
This class has the highest genetic barrier to drug resistance.
What are protease inhibitors?
200
One-pill, once daily medications including an integrase inhibitor
What is Genvoya (EVG), Stribild (EVG) and Triumeq (DTG)?
200
The amount of calories a patient is required to eat with Complera (TDF/RPV/FTC).
What is 400 kcal?
200
These NRTIs also have activity against Hep B.
What is tenofovir (TDF), lamivudine (3TC), and emtricitabine (FTC)?
200
The three one-pill, once daily medications recommended for initial treatment in treatment naive patients.
What are Stribild (EVG/COBI/TDF/FTC), Triumeq (ABC/3TC/DTG), and Genvoya (EVG/COBI/TAF/FTC)?
200
Definition of Virologic Failure
What is the inability to achieve or maintain suppression of viral replication to an HIV RNA level <200 copies/mL
300
These two PIs are associated with increased risk of kidney stones/cholethiasis.
What are atazanavir (ATV) and indinavir (IDV)?
300
Patients with an HVL >100,000 are more likely to fail with this NNRTI.
What is rilpivirine (RPV)?
300
This NRTIs is the only NRTI dose adjusted for hepatic impairment and NOT renal impairment.
What is abacavir (ABC)?
300
Twice daily regimen recommended for initial treatment in treatment naive patients.
What is Isentress (RAL) + Truvada (FTC/TDF)?
300
These three ARVs interact with proton-pump inhibitors (PPI) and are either contraindicated or require dose adjustment.
What are atazanavir (ATV), rilpivirine (RPV), tipranavir (TPV/r)?
400
Caution use of these two PIs in patients with sulfa allergies.
What are darunavir (DRV) and fosamprenavir (FPV)?
400
These two NNRTIs are included in which two one-pill, once daily regimens that are no longer preferred for initial treatment
What is efavirenz (EFV) in Atripla and rilpivirine (RPV) in Complera?
400
This is the reason tenofovir alafenamide (TAF) differs and may be favorable to tenofovir disoproxil fumarate (TDF).
What is TAF is more potent and requires lower dosing which may decrease long term adverse effects (BMD loss and kidney impairment)?
400
HIV-2 is intrinsically resistant to this drug class regimen so initial treatment should be with this other drug class regimen.
What is resistant to NNRTIs and initial treatment with integrase based regimens?
400
Stribild can only be started in patients with this CrCl, and it should be discontinued in patients already taking it if their CrCl drops below this value.
What is > 70 ml/min and < 50 ml/min?
500
These two PIs have been associated with QT prolongation.
What are lopinavir (LPV) and saquinavir (SQV)?
500
Some clinicians recommend increasing the dose of this NNRTI when given with rifampin.
What is EFV? (600 to 800 mg based on PK models. Would use 600mg, could check trough, goal 1000 ng/ml)
500
Associated with high level resistance to 3TC and FTC, but may increase susceptibility to TDF and ZDV.
What is the M184V mutation?
500
This PI with this dosing is the only available PI that is not contraindicated for use with Viekira Pak(Ombitasvir/Paritaprevir/ Ritonavir + Dasabuvir) for HCV.
What is atazanavir (ATV) without an additional booster dose reduced to 300 mg in AM at the same time as Viekira?
500
Name the components and brand names of the five available one pill once daily regimens.
What are Atripla (TDF/FTC/EFV), Complera (TDF/FTC/RPV), Stribild (EVG/COBI/TDF/FTC), Triumeq (ABC/3TC/DTG), and Genvoya (EVG/COBI/TAF/FTC)?