Neoplastic Nasties
Microscopic Mysteries
Slamin Lamins
Grossing Goobers
Buckle Up
100
This phenotype of adenocarcinoma confers a worse prognosis with high propensity for metastasis. Diagnosis? 
Signet ring cell adenocarcinoma
100
11 M with a dilated appendix. Diagnosis?
Lymphoid hyperplasia
100
Clinical term for apparent mucinous ascites or peritoneal mucin deposition.
Pseudomyxoma peritonei
100
Describe this appendix
Hyperemia, mural edema, and serosal purulent exudate
100
What non-expensive (in-clinic or at home) test can be used to confirm diagnosis?
Cellophane/Scotch tape test.
- Enterobius vermicularis has cuticle, eggs are distinctly compressed laterally and flattened on one side
Enterobius vermicularis
200
Synaptophysin++, Mucicarmine -
Diagnosis?
Well differentiated neuroendocrine tumor, Appendiceal carcinoid tumor
200
Most common bacterial organism is associated with this entity?
Yersinia.
Bonus: Most common fungal organism and most common non-infectious cause?
200
Diagnosis?
Low grade appendiceal mucinous neoplasm (LAMN)
200
FUN FACT: This Seattle philanthropist and Microsoft co-founder donated $300 million to fund brain research in 2003.
Paul Allen
200
Omental nodule with this: 
PAX8+, SATB2-
Diagnosis?
Ovarian mucinous neoplasm
300
Name the lesion. Name that mutation (2 of them).
KRAS & BRAF
Sessile serrated lesion
300
Transmural inflammation in a 64F s/p heart transplant. Diagnosis?
CMV appendicitis
300
Diagnosis?
High grade appendiceal mucinous neoplasm (HAMN)
300
300
17 M with distended appendix and chronic cough. Diagnosis? 
Cystic Fibrosis
400
Tip of the appendix, high power shows this. Mucicarmine +
Synaptophysin:
Diagnosis?
Goblet Cell Adenocarcinoma
400
24 F with a sub-serosal lesion. Diagnosis? 
Endometriosis
400
Which finding associated with an appendiceal mucinous neoplasm has the greatest risk of progression?
- Acellular mucin outside the right lower quadrant of abdomen
- Acellular mucin restricted to right lower quadrant of abdomen
- Extra-appendiceal mucin containing low grade epithelium
- High grade epithelium confined to appendix
- Low grade epithelium confined to appendix
- Extra-appendiceal mucin containing low grade epithelium
400
Diagnosis?
Fibrous Obliteration of the Tip
400
MED SCHOOL THROW BACK!
Name 3 physical exam "signs" that are commonly described in acute appendicitis. Name all 4 for double the points.
McBurney's point
Rovsing's sign
The psoas sign
The obturator sign
500
Name two other manifestations associated with syndromic pancreatic neuroendocrine tumors.
BONUS: This Seattle-based band's debut album "Deep Six" is considered one of the first grunge releases, predating Nirvana and Pearl Jam.
EXTRA Bonus: Name a founding member that has been the band's only constant member.
MEN1; Pit adenoma and parathyroid hyperplasia
The Melvins
Buzz Osborne (King Buzzo)
500
Non-obliterative spindle cell lesion in the appendiceal tip of a 15 year old with freckles in the armpits. What is the associated syndrome? 
Neurofibromatosis 1, von Recklinghausen
500
This chromosomal location houses the gene most frequently mutated in LAMN and HAMN
12p12.1 (KRAS)
500
45 M with constipation. Diagnosis?
Appendiceal diverticulosis
500
Associated with rectal prolapse. 
Trichuris trichiura (Whip worm)
1000
40 unvaccinated F with a rash that appeared after appendectomy. Large multinucleated cells are seen scattered and in the germinal centers. What is the name of these large cells?
Warthin-Finkeldey cells (Measels)