Melanoma
Most common mutation in melanoma
BRAF-V600E
Median engraftment time for allogeneic transplant
22 (14-28) days
This gene modifying technology has been used to treat SCD
CRISPR
CAR-T for multiple myeloma targets what protein?
BCMA
This CXCR4 antagonist allows for the release of stem cells into the periphery for collection
Plerixafor
Melanoma <2mm in depth needs what margin width?
1cm
This JAK inhibitor is approved for steroid refractory acute GVHD
Ruxolitinib/Jakafi
Glu > Val
MOA of tocilizumab
IL-6 receptor inhibitor
60% of patients on BRAF-MEK inhibitors experience what side effect
Pyrexia
2 adjuvant treatment options for high risk stage II/III melanoma
Nivolumab
Pembrolizumab
Dabrafenib/trametinib if BRAF V600 mutation positive
What grade acute GVHD
Rash >50% BSA (no other organs involved)
Grade 2
This drug increases nicotinamide adenine dinucleotide in sickle red blood cells
L-Glutamine/Endari
Grade the CRS:
Fever 101.5, BP 90/50, O2 90% on 2L NC
2
Name 3 drugs that can be used for PJP ppx
Bactrim, Dapsone, Atovaquone, Pentamidine
This genetic syndrome is associated with clear cell RCC and melanoma
BAP-1
CMV reactivation usually happens around what day
D+100
HbSC is associated with a higher rate of _________ compared to SS
Retinopathy or Bone Infarcts
Name 2 Anti CD-19 CAR-Ts
Tisa-cel (Kymriah)
Liso-cel (Breyanzi)
Axi-cel (Yescarta)
Brexu-cel (Tecartus)
Busulfan has a high risk of what 2 complications when used as a txt conditioning regimen
Seizures
VOD
Tebentafusp/Kimmtrak requires what positive blood test in metastatic uveal melanoma patients?
HLA-A*02:01
9/10 MRD (sib) > 10/10 MUD - why?
Minor histocompatibility complexes
P-selectin Inhibitor used for treatment of SCD
Crizanlizumab
This medication has been proposed for steroid-refractory CRS/ICANS
anakinra
MOA of Belumosudil
ROCK inhibitor