GABAergic Imbalance
What is the primary role of GABA?
What is inhibiting neurons?
What is the SHANK3 gene associated with?
what is synaptic function?
How does ASD symptom severity differ by gender?
What is milder in females?
Define "neurotransmitter."
What is a chemical messenger?
What does ASD stand for?
What is Autism Spectrum Disorder?
How do GABA levels in ASD differ from typical levels?
What is higher or lower?
How do SHANK3 mutations affect synapses?
What is disrupted density?
What specific role does GABA play in males with ASD?
What is lowering symptoms?
Explain why thalamic GABA concentration is a focal point for ASD research.
What is sensory regulation?
List two core symptoms of ASD.
What are social deficits and repetitive behaviors?
Describe GABA’s impact on sensory processing.
What is balancing response?
Explain the connection between SHANK3 mutations and ASD behaviors.
What is reduced connectivity?
Why is studying gender-specific traits important in ASD?
What is tailored treatment?
What is one key limitation of the experiment on GABA in ASD?
What is small sample size?
Why is ASD considered a spectrum disorder?
What is symptom variety?
Name one brain region where GABA levels differ in ASD.
What is dorsolateral prefrontal cortex (DLPFC)?
What would be an observed effect of SHANK3 mutation on synaptic density?
What is fewer synapses?
Describe a finding unique to males with ASD regarding thalamic GABA levels.
What is negative correlation?
Why is it important to measure both GABA concentrations and GABAA receptor densities?
What is fuller picture?
Explain the concept of "excitation/inhibition imbalance" in ASD.
What is too much excitation?
How does an imbalance in GABA lead to hyperactivity in neurons?
What is lack of inhibition?
What therapeutic approach could target SHANK3-related synaptic issues?
What is gene therapy?
What is the relationship between GABA levels and socio-communicative skills in females with ASD?
What is positive correlation?
Describe the method used to measure GABA in the study.
What is 1H-MRS?
How might ASD’s genetic diversity impact treatment approaches?
What is personalized therapy?