ASTHMA

Background

100

Predominant feature that causes asthma symptoms 

Bronchoconstriction 

200

Risk factors 

Environmental factors (pollution, smoke, diet) 

GERD
Emotions 

Drugs 

Exercise 

Occupational stimuli 

300

Compare and contrast genetic VS environmental asthma 

Genetic:

Strong family history, onset <12 years old

Environmental: 

Innate immunity (Hygiene hypothesis), onset >12 years old 

400

Airway remodeling results in

Persistant changes in airway structure 

Can eventually lead to COPD

500

Pathophysiology of airway edema 

Mast cells release histamine 

Occurs with edema, mucus hyper section, mucus plugs 

Treatment

100

True or false: You can use LAMA as monotherapy in asthma 

False 

200

Non-pharmacologic treatment 

Remove risk factors

Physically activity and diet 

Relieve stress 

Influenza vaccine 

300

Asthma symptoms three times a month 

PRN low dose ICS-formoterol 

400

Risks of SABA only treatment 

Beta-receptor down regulation

Rebound hyper-responsiveness 

Decreased bronchodilator response 

Higher risk of severe exacerbation 

500

What are the 3 types of immunomodulators 

IgE antibody 

IL4 receptor inhibitor 

IL5/IL5 receptor inhibitor 

Clinical presentation

100

Symptoms of chronic asthma 

Dyspnea 

Chest tightness 

Coughing (night)

Wheezing

200

What type of asthma has a poor response to bronchodilators 

Sever asthma 

300

Main clinical features 

Bronchoconstriction 

Airway edema 

Airway hyperresponsiveness

400

Excessive bronchoconstriction due to an increased sensitivity to triggers 

Airway hyper-responsiveness

500

Factors influencing nocturnal asthma 

Lung function decreases during sleep = worsening asthma symptoms 

Indicates inadequate treatment 

Exacerbations

100

True or false: IV Mg is 1st line for asthma exacerbation 

False 

200

Not recommended for exacerbation 

Sedation

Antibiotics 

Methylxanthine 

300

How are systemic oral corticosteroids administered 

Ideally used as a “burst” to stop exacerbation worsening, speed recovery, and prevent relapse 

400

What is included in an asthma action plan

Daily management

Recognizing and managing worsening asthma 

Especially beneficial if: moderate to persistent asthma, history of exacerbations, poorly controlled asthma 

 

500

 Class of medication that reduces beta down regulation and improves SABA sensitivity 

Systemic oral corticosteroids 

Misc.

100

Disease of chronic inflammation leading to airway obstruction 

Asthma 

200

When do you reassess therapy after stepping up controller medications 

2-3 months 

300

Goals of therapy 

Reduce impairment 

Reduce risk 

400

Pharmacists Role 

Inhaler technique 

Role of medications 

Asthma action plan 

Evaluate drug utilization 

500

What is Lindseys middle name

Villanueva