Predominant feature that causes asthma symptoms
Bronchoconstriction
True or false: You can use LAMA as monotherapy in asthma
False
Symptoms of chronic asthma
Dyspnea
Chest tightness
Coughing (night)
Wheezing
True or false: IV Mg is 1st line for asthma exacerbation
False
Asthma
Risk factors
Environmental factors (pollution, smoke, diet)
GERD
Emotions
Drugs
Exercise
Occupational stimuli
Non-pharmacologic treatment
Remove risk factors
Physically activity and diet
Relieve stress
Influenza vaccine
What type of asthma has a poor response to bronchodilators
Sever asthma
Not recommended for exacerbation
Sedation
Antibiotics
Methylxanthine
When do you reassess therapy after stepping up controller medications
2-3 months
Compare and contrast genetic VS environmental asthma
Genetic:
Strong family history, onset <12 years old
Environmental:
Innate immunity (Hygiene hypothesis), onset >12 years old
Asthma symptoms three times a month
PRN low dose ICS-formoterol
Main clinical features
Bronchoconstriction
Airway edema
Airway hyperresponsiveness
How are systemic oral corticosteroids administered
Goals of therapy
Reduce impairment
Reduce risk
Airway remodeling results in
Persistant changes in airway structure
Can eventually lead to COPD
Risks of SABA only treatment
Beta-receptor down regulation
Rebound hyper-responsiveness
Decreased bronchodilator response
Higher risk of severe exacerbation
Excessive bronchoconstriction due to an increased sensitivity to triggers
Airway hyper-responsiveness
What is included in an asthma action plan
Recognizing and managing worsening asthma
Especially beneficial if: moderate to persistent asthma, history of exacerbations, poorly controlled asthma
Pharmacists Role
Inhaler technique
Role of medications
Asthma action plan
Evaluate drug utilization
Pathophysiology of airway edema
Mast cells release histamine
Occurs with edema, mucus hyper section, mucus plugs
What are the 3 types of immunomodulators
IgE antibody
IL4 receptor inhibitor
IL5/IL5 receptor inhibitor
Factors influencing nocturnal asthma
Lung function decreases during sleep = worsening asthma symptoms
Indicates inadequate treatment
Class of medication that reduces beta down regulation and improves SABA sensitivity
Systemic oral corticosteroids
What is Lindseys middle name
Villanueva