immunosuppressant drugs
these drugs interfere with production/function of immune cells, these will decrease these?
undesirable immune response
drug induced immunosuppression is a major part of transplantation protocols; without them we have inadequate immunosuppression and can result in this?
rejection, graft versus host disease and serious infection
these are cytotoxic immunosuppressant agents, what is this called?
mycophenolate mofetil
we utilize these, corticosteroids, they are considered what medications with immunosuppressant drugs?
adjuvant medications
these act rapidly, risk is r/t serious infection, drug in this class is methotrexate, that is this agent called?
tumor necrosis factor-alpha blocking agents
these also prevent immune system from targeting own body tissues for elimination, they are used in these specific cases, what are they?
allergic reactions, autoimmune disorders, post tissue and organ transplant
an acute reaction can occur in this time range posttransplant, have characteristics of signs of organ failure and inflammation of blood vessels which lead to arterial narrowing /obliteration
10 days to a few months
these are conventional antirejection agents, what is this?
cyclosporine
these are immunoglobin preparations that stimulate immune response are called what?
antibody preparations
this is used in rheumatoid arthrits and binds and blocks inflammation, what is this agent called?
interleukin blocking agents
this occurs when the patient's immune system does not distinguish between domestic(self) and foreign (non-self) cells, what is this disorder?
autoimmune disorder
Chronic reactions, have characteristics of firbrois sof blood vessels and progresive failure of transplanted organ, what is this time frame?
occur after months or years of normal functioning
these are Janus-associated kinase inhibitor, what is this?
ruxolitinib
this type of antibody preparations reacts with a specific cell antigen to alter immune response to an antigen, what type is this?
monoclonal
this is an IgG antibody that binds to antigen-prevents activation of T lymph phagocytes and production of inflammatory cytokines, what is this inhibitor called?
fusion protein inhibitors
what are some of the inflammatory disorders that are treated with immunosuppressant medications?
allergic conditions, allergic asthma, Crohn's, psoriasis, psoriatic arthritis, rheumatoid arthritis
what is the black box warning on mycophenolate mofetil?
fetal loss or malformation
this type of antibody preparations is a mixed antibodies of Ig A,D,E, G and M, what is this type called?
polyclonal
what is the black box warning for cyclosporine?
hypertension and nephrotoxicity