Is it needed?
Dr. Dalal sees a patient who presents with fever, chills, and noticeable splenomegaly. The patient recently traveled to a region where SubSaharan Africa. What is the most likely diagnosis?
Malaria
A 32-year-old male presents with a 7-day history of progressive weakness, starting in his feet. He reports a recent viral upper respiratory infection about two weeks prior.
On examination, he has diminished deep tendon reflexes, weakness in both lower limbs, and facial drooping.
Cerebrospinal fluid analysis shows an elevated protein level (100 mg/dL) with a normal white cell count, and nerve conduction studies reveal markedly slowed nerve conduction velocities.
The patient’s symptoms rapidly worsen, leading to difficulty breathing. What is the most likely diagnosis?
Guillain-Barré Syndrome (GBS)
A patient on warfarin develops skin necrosis. What deficiency should be considered?
Protein C deficiency
A 45-year-old male presents to the emergency department with sudden onset of severe chest pain that started about 30 minutes ago. The pain is sharp, radiates to his left arm, and is associated with shortness of breath and sweating. He has a history of hypertension and is a smoker. On examination, his blood pressure is 145/90 mmHg, heart rate is 98 bpm, and respiratory rate is 22 breaths/min. An ECG shows ST-segment elevation in leads II, III, and aVF. Cardiac enzymes are elevated. The most appropriate immediate treatment is?
Urgent percutaneous coronary intervention (PCI)
Italian goalkeeper, widely regarded as one of the best in history, played the majority of his career at Juventus and the Italian national team?
Gianluigi Buffon
A 55-year-old male presents with splenomegaly, fatigue, and an elevated red blood cell count. He has a history of headaches. What is the most likely diagnosis?
Polycythemia vera
A 45-year-old woman with no significant past medical history presents for a routine physical exam. She reports no current symptoms, but a recent chest X-ray shows a small, healed apical scar.
She has no history of active tuberculosis (TB), but her father had TB many years ago.
A tuberculin skin test (TST) is positive with a 14 mm induration, but her sputum smears and cultures are negative for Mycobacterium tuberculosis. She is asymptomatic and has no risk factors for progression to active disease.
What is the most likely diagnosis?
Latent TB
A 35-year-old patient presents with bleeding gums, fatigue, and joint pain. The condition is linked to a deficiency in a vitamin commonly found in some fruits and leafy greens?
Vitamin C deficiency
A 28-year-old female presents with abdominal pain, bloating, diarrhea, fatigue, and weight loss over the past few months. She has a history of iron-deficiency anemia and recurrent mouth ulcers. Lab results show low iron and low ferritin. A duodenal biopsy confirms villous atrophy. What is the most appropriate treatment for this patient?
Lifelong gluten-free diet
ما هو اسم المحقق الذي يعمل مع كونان في التحقيقات؟
توغو موري
A 60 year old male with splenomegaly, pancytopenia and posutive TRAP staining; what is the disgnosis?
Hairy cell leukemia
A 42-year-old woman presents with unexplained infertility and a history of recurrent miscarriages. She also reports a few months of depression, brittle nails, and unexplained muscle cramps.
On examination, she has slow heart rate (bradycardia). Her lab results show an TSH of 12.3 mU/L, low free T4. What is the most likely diagnosis?
Hashimoto’s thyroiditis
A 25-year-old patient presents with tremors, hepatic dysfunction and psychiatric symptoms. The condition is caused by a genetic mutation that leads to a metal buildup in the body?
Wilson's disease
A 16-year-old girl is brought to the clinic with a 3-week history of swelling around her eyes, along with increasing puffiness in her legs. Her urine has become frothy. On physical examination, she has periorbital edema, pitting edema in both lower extremities, and a blood pressure of 100/65 mmHg. Laboratory results reveal:
Serum albumin: 1.8 g/dL (L). Serum cholesterol: 280 mg/dL (H). Urine dipstick: 3+ proteinuria. 24-hour urine protein excretion: 3.8 g/day (H). Serum creatinine: 0.6 mg/dL (N).
A kidney biopsy is not performed at this time, but the clinical presentation is highly suggestive of minimal change disease (MCD). What is the most appropriate first-line treatment for this patient?
Corticosteroids
Swedish striker is known for his larger-than-life personality and has played for several top clubs, including Barcelona, Paris Saint-Germain, and Manchester United?
Zlatan Ibrahimović
A 40-year-old patient presents with fatigue, dry cough, shortness of breath, and splenomegaly. Chest X-ray reveals bilateral hilar lymphadenopathy, and a biopsy shows noncaseating granulomas. What is the most likely diagnosis?
Sarcoidosis
A 55-year-old diabetic male presents with a 5-day history of fever, localized bone pain, and swelling in his right foot after a recent minor foot injury. He has redness and warmth over the affected area, and his white blood cell count is elevated. An X-ray shows a lytic lesion in the bone. Blood cultures grow Staphylococcus aureus. What is the most likely diagnosis?
Osteomyelitis
A 45-year-old patient presents with fatigue, joint pain, and liver enlargement. Genetic testing reveals a mutation that causes excessive absorption of a metal and accumulation in various organs?
Hemochromatosis
A 40-year-old male presents to the emergency department with complaints of confusion, headache, and nausea that have worsened over the past 24 hours. He also reports increased thirst and a recent history of vomiting and diarrhea for the past few days due to a gastrointestinal illness. On physical examination, he is lethargic and has dry mucous membranes, decreased skin turgor, and orthostatic hypotension. His blood pressure is 90/60 mmHg, heart rate is 110 bpm, and his weight has decreased by 2 kg over the past 3 days.
Laboratory results reveal: Sodium: 128 mEq/L. Serum osmolality: 270. Urine sodium: 25 mEq/L. Urine osmolality: 500 mOsm/kg.
Given the patient's presentation and laboratory findings, what is the most appropriate initial treatment for this patient?
Isotonic saline (0.9% sodium chloride)
في أي مدينة يعيش كونان؟
طوكيو
A 17-year-old patient presents with fever, hepatosplenomegaly, a rash, and severe cytopenias. Laboratory tests reveal elevated ferritin levels. What rare, life-threatening condition is suspected?
Hemophagocytic lymphohistiocytosis (HLH)
A 58-year-old man with a history of extensive sun exposure presents with a slow-growing, pearly, nodular lesion on his nose.
The lesion has a central ulceration with raised, rolled borders, and small telangiectatic vessels are visible on its surface.
Despite being present for over a year, it is asymptomatic and has not changed significantly in size. What is the most likely diagnosis?
Basal cell carcinoma
A 32-year-old patient with a history of recurrent fevers, abdominal pain, and arthritis presents with signs of organ dysfunction. Genetic testing reveals a mutation linked to periodic inflammation. What is the most likely diagnosis?
Familial Mediterranean fever complicated by AA amyloidosis
A 45-year-old woman presents with progressive difficulty swallowing, slurred speech, and drooping eyelids. She also has weak oropharyngeal muscles and ptosis. A positive tensilon test supports the diagnosis. What is the most likely diagnosis, and the treatment?
Acetylcholinesterase inhibitor and immunosuppressive therapy(Corticosteroids) + IVIG
Croatian midfielder was instrumental in leading his national team to the 2018 World Cup final and won the Ballon d'Or in the same year?
Luka Modrić