Mycoplasm
True or False? Mycoplasma have a thin layer of peptidoglycan in their cell walls
FALSE: no cell wall
What is the most common isolate from small animal UTIs?
E. coli
Can you get the plague from a dog flea?
NO rodent fleas only
What is the primary virulence factor of Pasteurella multocida (important in progression of atrophic rhinitis)
Pasteurella multocida toxin (PMT)
What species makes cat bites such a b!tch?
Pasteurella multocida
(even Rajeev says don't wait for susceptibility testing)
Hemotrophic mycoplasma preferentially infect what kind of cells?
Blood cells
Why are neonatal pigs and calves vulnerable to colibacillosis and not adults?
Expression of K99 fimbriae in calves
K88 fibriae in piglets
What is the most common local and most common systemic disease state associated with Salmonella?
diarrhea
septicemia
What are the most common isolates in cows with BRDC/Shipping Fever Pneumonia
P. multocida
Manheimia hemolytica
Mycoplasma bovis
Trueperella pyogenes
Histophilus somni (discussed in review, not on slide)
What is the major virulence factor of Mannheimia haemolytica ( a common isolate from BRDC) and what does it do?
Leukotoxin- forms pores in WBCs, destroying them and inducing immunosuppression
What disease is associated with Mycoplasma mycoides subsp. mycoides?
Contagious bovine pleuropneumonia
What causes the edema produced by edema disease?
Shiga-like toxins produced by E. coli which destroys endothelium
What virulence factor allows Salmonella to inject proteins directly into cells without them encountering the extracellular environment?
Type III secretion system
What disease state does P. multocida produce in birds?
Fowl Cholera (mature birds more susceptible, used to prove efficacy of bacterin vaccines)
What are the main lesions of Haemophilus parasuis (Glasser's disease)?
polyserositis
polysynovitis
meningitis
What 3 disease states are associated with Mycoplasma bovis in cattle?
pneumonia (BRDC), arthritis, mastitis
Why should you not submit a suspected E. coli sample in a blood tube?
it just starts blastin
(anaerobic environment > fermentation > vial bursts from gas pressure)
What two types of Salmonella produce disease state in poultry?
Salmonella serotype Pullorum (bacillary white diarrhea in chicks- mishapen ovaries)
Salmonella serotype Gallinarum (Fowl typhoid - bronze liver)
What organism causes REGRESSIVE atrophic rhinitis and what is the function of its virulence factor?
Bordetella bronchiseptica
Dermonecrotic toxin - inhibits osteoblasts
What syndrome can occur in animals following pneumonia caused by Histophilus somni and what are its associated symptoms?
Thromboembolic meningoencephalitis (sleeper syndrome)
ataxia, convulsions, depression, coma, death
hemorrhage and necrosis in brain
What Mycoplasma spp. causes caprine pleuropneumonia in sheep and goats?
M. capricolum subsp. capripneumoniae
How does E. coli attach to and destroy intestinal villi?
Producing intimin receptors that translocate to the villus and bind to intimin expressed on the cell surface
Name one of the other member of Enterobacteriaceae that exhibit emerging antibiotic resistance (many also common isolates from small animal UTIs)
Proteus vulgaris, Proteus mirabilis, Klebsiella pneumoniae
What significant disease in rabbits is caused by P. multocida type A?
Respiratory Tract Disease (Snuffles)
What is the bacteria responsible and symptoms of Fowl Coryza?
Avibacterium paragallinarum
swelling of eyes and wattles
oculonasal discharge
diarrhea