CMV
Exotic
Diagnostic Pearls
Outbreaks
Novels
100

Mutations in this CMV gene confer resistance to both ganciclovir and cidofovir.

What is UL54 (DNA polymerase)?

100

This rodent-borne arenavirus is the cause of hemorrhagic fever in West Africa and is often transmitted via Mastomys natalensis. Can cause hearing loss

What is Lassa virus?

100

This test is the gold standard for diagnosing malaria.

What is a peripheral blood smear (thick and thin)?

100

This London physician famously linked a cholera outbreak to a contaminated water pump in 1854.

Who is John Snow?

100

This drug is a lipoglycopeptide with activity against MRSA and can be dosed once weekly

What is dalbavancin?

200

This congenital infection is the leading infectious cause of hearing loss in children in the U.S.

What is CMV?

200

This zoonotic orthopoxvirus caused outbreaks in the U.S. in 2003 linked to prairie dogs and Gambian pouched rats.

What is monkeypox (mpox)?

200

The presence of Maltese cross formations in red blood cells is pathognomonic for this protozoan infection.

What is Babesia microti?

200

This disease caused the 1918 global pandemic known as the Spanish Flu.

What is influenza A (H1N1)?

200

This oxazolidinone is active against VRE and has reduced mitochondrial toxicity compared to linezolid.

What is tedizolid?

300

This new terminase inhibitor is approved for CMV prophylaxis in transplant patients.

What is letermovir?

300

This tick-borne bunyavirus, first identified in China in 2011, causes severe fever with thrombocytopenia.

What is SFTS virus? Severe Fever with Thrombocytopenia Syndrome

300

This infection presents with “safety pin” bipolar staining on Wright or Giemsa stains.

What is Yersinia pestis?

300

The first recognized outbreak of Legionnaires’ disease occurred in 1976 at a convention in this U.S. city.

What is Philadelphia?

300

This new boronate β-lactamase inhibitor is combined with cefepime for MDR Gram-negative infections.

What is taniborbactam?

400

This drug, originally developed as an anti-influenza agent, is used for refractory resistant CMV infections.

What is maribavir?

400

This bacterium, found in the region of the Andes mountains is transmitted through the bite of a sandfly and causes Oroya fever/verruga peruana

What is Bartonella bacilliformis?

400

Urine legionella antigen detects only what serogroup?

What is Legionella pneumophila serogroup 1?

400

The discovery of this pathogen in 1977 in northern Somalia was considered the last natural case of smallpox.

What is Variola minor?

also called white pox, kaffir pox, Cuban itch, West Indian pox, milk pox, and pseudovariola.

400

This combination of ceftazidime and a non-β-lactam β-lactamase inhibitor is specifically designed to treat MBL-producing organisms.

What is ceftazidime-avibactam + aztreonam?

500

This agent of rat-bite fever is a gram-negative spiral rod that does not stain well with Gram stain.

What is Spirillum minus?

500

The “string test” with a swallowed gelatin capsule is a historical diagnostic tool for this protozoan.

What is Giardia lamblia?

500

This city experienced a devastating yellow fever outbreak in 1878, leading to over 5,000 deaths.

What is Memphis, Tennessee?

500

This anti-CMV drug is a UL97 kinase-independent agent with a unique mechanism of action.

What is maribavir?