BDNF
Brain Derived Neurotrophic Factor
What is BDNF?
A progressive brain disorder causing uncontrolled movements
What is Huntington's disease?
The animal model used in this study
What is R6/2 mice?
This class
What is Advanced Neurobiology?
A neurotrophin that often acts as a neuroprotectant
What is BDNF?
Chorea, hyperkinesis, and cognitive deficits.
What are HD symptoms?
Showed the greatest % decrease in BDNF
What is exon IV?
Mutant huntingtin proteins clump together
Protein aggregates
BDNF promotes
What is neuronal growth and differentiation?
The mutation in the HTT gene.
What is CAG trinucleotide repeat?
What is RT-PCR?
Species of animal Tariq knows the most about
What is Drosophila?
Reduces the amount of BDNF in the striatum
What is mutant huntingtin?
Measured in electrophoresis
What is BDNF promoter?
Represses the transcription of BDNF
What is NRSE?