Pharmacodynamics
This is a very common second messenger in GPCR signaling from drug targets.
What is cAMP?
This component of PK increases the water solubility of the drug for transport through the circulatory system.
What is Metabolism?
True or False: Drugs are tested in humans first and only during drug development
What is False?
True or False: Signal Transduction and therefore drug signaling can only produce one response molecule at a time.
What is false?
This route of drug administration has 100% bioavailability
What is Intravenous (IV)?
This phase of drug development determines the mechanism of action of the drug.
What is preclinical?
This is the name for a drug molecule that produces the same biological response as the receptor ligand
What is agonist?
This class of enzymes is the primary drug metabolizing enzyme class
What is the CYP450s?
When pH<pKa, then a basic drug will be positively charged, neutrally charged, or negatively charged
What is positively charged?
This phase of drug development is the final phase before drug approval.
What is Phase 3?
Drug A is an inducer of CYP3A4 which metabolizes Drug B. When administered together the effect on [Drug B] is...
What decreases [Drug B]?
This is the location for the receptors for lipophilic drugs
What is the cytosol/nucleus?
This route of drug administration bypasses first pass metabolism but from the other end of oral drug administration
What is rectal?
This phase of metabolism involves conjugation reactions and typically inactivates the drug.
What is Phase II?
Drug A is an inhibitor of CYP2D6 and Drug B requires CYP2D6 to become the active drug form. When administered together the effect on [Drug B] is
What is decreased [Drug B]?
True or False: Only agonists can increase the activity of a receptor.
What is false
This is the relative percentage of Phase 3 Clinical Trials that bring a drug to market.
What is 30%?
DAILY DOUBLE!
What mechanism of drug absorption requires energy input?
What is Active transport
These drugs are the most dangerous to monitor with respect to drug-drug interactions.
What is narrow therapeutic windown/